TY - JOUR
T1 - Well differentiated follicular thyroid neoplasia
T2 - Impact of molecular and technological advances on detection, monitoring and treatment
AU - Gianoukakis, Andrew G.
AU - Giannelli, Silvana M.
AU - Salameh, Wael A.
AU - McPhaul, Laron W.
N1 - Our understanding of the molecular mechanisms responsible for follicular thyroid cell oncogenesis has been advanced significantly in recent years. Spe...
PY - 2011/1/30
Y1 - 2011/1/30
N2 - Our understanding of the molecular mechanisms responsible for follicular thyroid cell oncogenesis has been advanced significantly in recent years. Specific genetic alterations and the molecular pathways they affect have been associated with particular histologic subtypes of well-differentiated thyroid cancer and are now being evaluated for their utility as clinical tools with diagnostic, prognostic and even therapeutic relevance. This paper focuses on the most common and clinically relevant genetic alterations shown to be consistently associated with well-differentiated thyroid carcinoma. We review the impact of recent molecular and technological advances on thyroid cancer standard of care and the practice of clinical medicine.
AB - Our understanding of the molecular mechanisms responsible for follicular thyroid cell oncogenesis has been advanced significantly in recent years. Specific genetic alterations and the molecular pathways they affect have been associated with particular histologic subtypes of well-differentiated thyroid cancer and are now being evaluated for their utility as clinical tools with diagnostic, prognostic and even therapeutic relevance. This paper focuses on the most common and clinically relevant genetic alterations shown to be consistently associated with well-differentiated thyroid carcinoma. We review the impact of recent molecular and technological advances on thyroid cancer standard of care and the practice of clinical medicine.
KW - Anaplastic
KW - FNA
KW - Follicular thyroid cancer
KW - Papillary thyroid cancer
KW - Thyroglobulin
KW - Thyroid cancer
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U2 - 10.1016/j.mce.2010.11.009
DO - 10.1016/j.mce.2010.11.009
M3 - Review article
C2 - 21094678
SN - 0303-7207
VL - 332
SP - 9
EP - 20
JO - Molecular and Cellular Endocrinology
JF - Molecular and Cellular Endocrinology
IS - 1-2
ER -