TY - JOUR
T1 - Voxel and surface-based topography of memory and executive deficits in mild cognitive impairment and Alzheimer's disease
AU - Nho, Kwangsik
AU - Risacher, Shannon L.
AU - Crane, Paul K.
AU - DeCarli, Charles
AU - Glymour, M. Maria
AU - Habeck, Christian
AU - Kim, Sungeun
AU - Lee, Grace J.
AU - Mormino, Elizabeth
AU - Mukherjee, Shubhabrata
AU - Shen, Li
AU - West, John D.
AU - Saykin, Andrew J.
N1 - Funding Information:
All individuals whose data were used in the preparation of this article were participants of the ADNI project (http:// adni.loni.ucla.edu/). ADNI was launched in 2003 to evaluate biomarkers of AD-related neuropathology in patients with mild cognitive impairment (MCI) and early AD. This multisite longitudinal study is supported by the National Institute on Aging (NIA), the National Institute of Biomedical Imaging and Bioengineering (NIBIB), the Food and Drug Administration (FDA), private pharmaceutical companies and non-profit organizations. ADNI participants were recruited from 59 sites across the U.S. and Canada and include approximately 200 HC, 400 people diagnosed with MCI, and 200 people diagnosed with early probable AD aged 55– 90 years. Written informed consent was obtained from all participants and the study was conducted with prior Institutional Review Board approval at each participating institution. Inclusion and exclusion criteria, clinical and neu-roimaging protocols, and other information about ADNI have been published previously (Risacher et al. 2009, 2010) and can be found at www.adni-info.org. All demographic information, neuropsychological test scores, and diagnostic information were downloaded from the ADNI clinical data repository (http://www.loni.ucla.edu/ADNI/).
Funding Information:
Data analysis was begun at the 2011 Conference on Advanced Psychometric Methods in Cognitive Aging Research, with conference grant support from the National Institute on Aging (NIA) R13 AG030995 (Mungas). Additional support for data management and the specific analyses reported here were provided by NIA R01 AG19771 (Saykin), P30 AG10133 (Saykin/Ghetti), R01 AG029672 (Crane), U01 AG024904 and P30 AG10129 (DeCarli), NSF IIS-1117335 (Shen), and P50 AG05136 (Raskind). SL Risacher was supported by a Clinical and Translational Science Institute (CTSI) Pre-doctoral Training Grant (TL1 RR025759).
PY - 2012/12
Y1 - 2012/12
N2 - Mild cognitive impairment (MCI) and Alzheimer's disease (AD) are associated with a progressive loss of cognitive abilities. In the present report, we assessed the relationship of memory and executive function with brain structure in a sample of 810 Alzheimer's Disease Neuroimaging Initiative (ADNI) participants, including 188 AD, 396 MCI, and 226 healthy older adults (HC). Composite scores of memory (ADNI-Mem) and executive function (ADNI-Exec) were generated by applying modern psychometric theory to item-level data from ADNI's neuropsychological battery. We performed voxel-based morphometry (VBM) and surface-based association (SurfStat) analyses to evaluate relationships of ADNI-Mem and ADNI-Exec with grey matter (GM) density and cortical thickness across the whole brain in the combined sample and within diagnostic groups. We observed strong associations between ADNI-Mem and medial and lateral temporal lobe atrophy. Lower ADNI-Exec scores were associated with advanced GM and cortical atrophy across broadly distributed regions, most impressively in the bilateral parietal and temporal lobes. We also evaluated ADNI-Exec adjusted for ADNI-Mem, and found associations with GM density and cortical thickness primarily in the bilateral parietal, temporal, and frontal lobes. Within-group analyses suggest these associations are strongest in patients with MCI and AD. The present study provides insight into the spatially unbiased associations between brain atrophy and memory and executive function, and underscores the importance of structural brain changes in early cognitive decline.
AB - Mild cognitive impairment (MCI) and Alzheimer's disease (AD) are associated with a progressive loss of cognitive abilities. In the present report, we assessed the relationship of memory and executive function with brain structure in a sample of 810 Alzheimer's Disease Neuroimaging Initiative (ADNI) participants, including 188 AD, 396 MCI, and 226 healthy older adults (HC). Composite scores of memory (ADNI-Mem) and executive function (ADNI-Exec) were generated by applying modern psychometric theory to item-level data from ADNI's neuropsychological battery. We performed voxel-based morphometry (VBM) and surface-based association (SurfStat) analyses to evaluate relationships of ADNI-Mem and ADNI-Exec with grey matter (GM) density and cortical thickness across the whole brain in the combined sample and within diagnostic groups. We observed strong associations between ADNI-Mem and medial and lateral temporal lobe atrophy. Lower ADNI-Exec scores were associated with advanced GM and cortical atrophy across broadly distributed regions, most impressively in the bilateral parietal and temporal lobes. We also evaluated ADNI-Exec adjusted for ADNI-Mem, and found associations with GM density and cortical thickness primarily in the bilateral parietal, temporal, and frontal lobes. Within-group analyses suggest these associations are strongest in patients with MCI and AD. The present study provides insight into the spatially unbiased associations between brain atrophy and memory and executive function, and underscores the importance of structural brain changes in early cognitive decline.
KW - Alzheimer's disease
KW - Executive function
KW - Memory
KW - Mild cognitive impairment
KW - Surface-based analysis
KW - Voxel-based morphometry (VBM)
UR - http://www.scopus.com/inward/record.url?scp=84871722511&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84871722511&partnerID=8YFLogxK
U2 - 10.1007/s11682-012-9203-2
DO - 10.1007/s11682-012-9203-2
M3 - Article
C2 - 23070747
SN - 1931-7557
VL - 6
SP - 551
EP - 567
JO - Brain Imaging and Behavior
JF - Brain Imaging and Behavior
IS - 4
ER -