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Vitreous induces heme oxygenase-1 expression mediated by transforming growth factor-β and reactive oxygen species generation in human retinal pigment epithelial cells

  • Ren Hartung
  • , Sunil K. Parapuram
  • , Ramapriya Ganti
  • , D. Margaret Hunt
  • , Kakarla V. Chalam
  • , Richard C. Hunt

Research output: Contribution to journal › Article › peer-review

Original languageEnglish
Pages (from-to)66-78
Number of pages13
JournalMolecular Vision
Volume13
StatePublished - Jan 24 2007
Externally publishedYes

ASJC Scopus Subject Areas

  • Ophthalmology

Keywords

  • Reactive Oxygen Species/metabolism
  • Receptor, Transforming Growth Factor-beta Type I
  • Phosphorylation
  • Cell Nucleus/metabolism
  • Protein Isoforms/metabolism
  • Humans
  • RNA, Messenger/antagonists & inhibitors
  • Cells, Cultured
  • Pigment Epithelium of Eye/cytology
  • Benzamides/pharmacology
  • Dioxoles/pharmacology
  • Proto-Oncogene Proteins c-fos/genetics
  • Receptors, Transforming Growth Factor beta/antagonists & inhibitors
  • Signal Transduction/drug effects
  • Transcription Factor AP-1/metabolism
  • Enzyme Activation/physiology
  • Metallothionein/genetics
  • Activin Receptors, Type I/antagonists & inhibitors
  • Mitogen-Activated Protein Kinases/metabolism
  • Vitreous Body/cytology
  • Biological Transport/physiology
  • Protein Serine-Threonine Kinases
  • Heme Oxygenase-1/biosynthesis
  • Transforming Growth Factor beta/physiology

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