Viral MRI contrast agents: Coordination of Gd by native virions and attachment of Gd complexes by azide-alkyne cycloaddition

Duane E. Prasuhn; Robert M. Yeh; Andre Obenaus; Marianne Manchester; M. G. Finn

doi:10.1039/b615084e

Viral MRI contrast agents: Coordination of Gd by native virions and attachment of Gd complexes by azide-alkyne cycloaddition

Duane E. Prasuhn
, Robert M. Yeh
, Andre Obenaus
, Marianne Manchester
, M. G. Finn

Non-Invasive Imaging Laboratory

Research output: Contribution to journal › Article › peer-review

Abstract

Icosahedral virus particles decorated with a Gd(DOTA) analogue by Cu-mediated azide-alkyne cycloaddition (CuAAC) and/or with Gd3+ ions by coordination to the viral nucleoprotein show increased T1 relaxivity relative to free Gd(DOTA) complexes in solution. © The Royal Society of Chemistry.

Original language	English
Pages (from-to)	1269-1271
Number of pages	3
Journal	Chemical Communications
Issue number	12
DOIs	https://doi.org/10.1039/b615084e
State	Published - Jan 15 2007

ASJC Scopus Subject Areas

Electronic, Optical and Magnetic Materials
Catalysis
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

Keywords

Alkynes/chemistry
Azides/chemistry
Comovirus/chemistry
Contrast Media
Crystallography, X-Ray
Cyclization
Gadolinium/chemistry
Magnetic Resonance Imaging/methods
Virion/chemistry

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title = "Viral MRI contrast agents: Coordination of Gd by native virions and attachment of Gd complexes by azide-alkyne cycloaddition",

abstract = "Icosahedral virus particles decorated with a Gd(DOTA) analogue by Cu-mediated azide-alkyne cycloaddition (CuAAC) and/or with Gd3+ ions by coordination to the viral nucleoprotein show increased T1 relaxivity relative to free Gd(DOTA) complexes in solution. {\textcopyright} The Royal Society of Chemistry.",

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doi = "10.1039/b615084e",

language = "English",

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AU - Prasuhn, Duane E.

AU - Yeh, Robert M.

AU - Obenaus, Andre

AU - Manchester, Marianne

AU - Finn, M. G.

PY - 2007/1/15

Y1 - 2007/1/15

N2 - Icosahedral virus particles decorated with a Gd(DOTA) analogue by Cu-mediated azide-alkyne cycloaddition (CuAAC) and/or with Gd3+ ions by coordination to the viral nucleoprotein show increased T1 relaxivity relative to free Gd(DOTA) complexes in solution. © The Royal Society of Chemistry.

AB - Icosahedral virus particles decorated with a Gd(DOTA) analogue by Cu-mediated azide-alkyne cycloaddition (CuAAC) and/or with Gd3+ ions by coordination to the viral nucleoprotein show increased T1 relaxivity relative to free Gd(DOTA) complexes in solution. © The Royal Society of Chemistry.

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KW - Azides/chemistry

KW - Comovirus/chemistry

KW - Contrast Media

KW - Crystallography, X-Ray

KW - Cyclization

KW - Gadolinium/chemistry

KW - Magnetic Resonance Imaging/methods

KW - Virion/chemistry

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Viral MRI contrast agents: Coordination of Gd by native virions and attachment of Gd complexes by azide-alkyne cycloaddition

Abstract

ASJC Scopus Subject Areas

Keywords

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