Viral MRI contrast agents: Coordination of Gd by native virions and attachment of Gd complexes by azide-alkyne cycloaddition

Duane E. Prasuhn; Robert M. Yeh; Andre Obenaus; Marianne Manchester; M. G. Finn

doi:10.1039/b615084e

Viral MRI contrast agents: Coordination of Gd by native virions and attachment of Gd complexes by azide-alkyne cycloaddition

Duane E. Prasuhn, Robert M. Yeh, Andre Obenaus, Marianne Manchester, M. G. Finn

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Abstract

Icosahedral virus particles decorated with a Gd(DOTA) analogue by Cu-mediated azide-alkyne cycloaddition (CuAAC) and/or with Gd³⁺ ions by coordination to the viral nucleoprotein show increased T₁ relaxivity relative to free Gd(DOTA) complexes in solution.

Original language	English
Pages (from-to)	1269-1271
Number of pages	3
Journal	Chemical Communications
Issue number	12
DOIs	https://doi.org/10.1039/b615084e
State	Published - 2007

ASJC Scopus Subject Areas

Electronic, Optical and Magnetic Materials
Catalysis
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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AU - Finn, M. G.

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Viral MRI contrast agents: Coordination of Gd by native virions and attachment of Gd complexes by azide-alkyne cycloaddition

Abstract

ASJC Scopus Subject Areas

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