Up-regulated HIF-1α is involved in the hypoxic tolerance induced by hyperbaric oxygen preconditioning

Zhaoyun Peng; Ping Ren; Zhimin Kang; Jing Du; Qinglin Lian; Yun Liu; John H. Zhang; Xuejun Sun

doi:10.1016/j.brainres.2008.03.027

Up-regulated HIF-1α is involved in the hypoxic tolerance induced by hyperbaric oxygen preconditioning

Zhaoyun Peng
, Ping Ren
, Zhimin Kang
, Jing Du
, Qinglin Lian
, Yun Liu
, John H. Zhang
, Xuejun Sun

Neurosurgery

Research output: Contribution to journal › Article › peer-review

Abstract

Hyperbaric oxygen preconditioning (HBO-PC) has been shown to be effective in preventing hypoxic injuries in many animal models. The aim of the present study was to examine the hypoxic tolerance induced by HBO-PC and to explore the role of hypoxia-inducible factor-1α (HIF-1α) in a global hypoxia model. Male mice received HBO-PC before hypoxia exposure and swimming. HBO-PC significantly prolonged the survival time and the tolerance time of swimming under normobaric hypoxia. HBO-PC increased the protein content of HIF-1α and erythropoietin (EPO) in the cerebral cortex and hippocampus and prevented the changes of blood brain barrier (BBB) permeability and brain edema caused by hypoxia exposure. The results suggested that HBO-PC induced hypoxic tolerance in mice via up-regulation of HIF-1α and its downstream genes. © 2008 Elsevier B.V. All rights reserved.

Original language	English
Pages (from-to)	71-78
Number of pages	8
Journal	Brain Research
Volume	1212
DOIs	https://doi.org/10.1016/j.brainres.2008.03.027
State	Published - May 30 2008

ASJC Scopus Subject Areas

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

Keywords

Hyperbaric oxygen preconditioning
Hypoxia-inducible factor-1α
Hypoxic tolerance
Erythropoietin/metabolism
Up-Regulation/physiology
Cerebral Cortex/metabolism
Ischemic Preconditioning
Hypoxia/complications
Hypoxia-Inducible Factor 1, alpha Subunit/genetics
Male
Mice, Inbred Strains
Behavior, Animal
Brain Edema/etiology
Animals
Analysis of Variance
Time Factors
Hippocampus/metabolism
Survival Analysis
Mice
Hyperbaric Oxygenation
Disease Models, Animal

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title = "Up-regulated HIF-1α is involved in the hypoxic tolerance induced by hyperbaric oxygen preconditioning",

abstract = "Hyperbaric oxygen preconditioning (HBO-PC) has been shown to be effective in preventing hypoxic injuries in many animal models. The aim of the present study was to examine the hypoxic tolerance induced by HBO-PC and to explore the role of hypoxia-inducible factor-1α (HIF-1α) in a global hypoxia model. Male mice received HBO-PC before hypoxia exposure and swimming. HBO-PC significantly prolonged the survival time and the tolerance time of swimming under normobaric hypoxia. HBO-PC increased the protein content of HIF-1α and erythropoietin (EPO) in the cerebral cortex and hippocampus and prevented the changes of blood brain barrier (BBB) permeability and brain edema caused by hypoxia exposure. The results suggested that HBO-PC induced hypoxic tolerance in mice via up-regulation of HIF-1α and its downstream genes. {\textcopyright} 2008 Elsevier B.V. All rights reserved.",

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author = "Zhaoyun Peng and Ping Ren and Zhimin Kang and Jing Du and Qinglin Lian and Yun Liu and Zhang, \{John H.\} and Xuejun Sun",

note = "Funding Information: We thank Qingjuan Tang and Pengfei Guo for their contributions to this work. This work was supported by the National Nature Science Foundation of China (No. 30500579).",

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AU - Peng, Zhaoyun

AU - Ren, Ping

AU - Kang, Zhimin

AU - Du, Jing

AU - Lian, Qinglin

AU - Liu, Yun

AU - Zhang, John H.

AU - Sun, Xuejun

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N2 - Hyperbaric oxygen preconditioning (HBO-PC) has been shown to be effective in preventing hypoxic injuries in many animal models. The aim of the present study was to examine the hypoxic tolerance induced by HBO-PC and to explore the role of hypoxia-inducible factor-1α (HIF-1α) in a global hypoxia model. Male mice received HBO-PC before hypoxia exposure and swimming. HBO-PC significantly prolonged the survival time and the tolerance time of swimming under normobaric hypoxia. HBO-PC increased the protein content of HIF-1α and erythropoietin (EPO) in the cerebral cortex and hippocampus and prevented the changes of blood brain barrier (BBB) permeability and brain edema caused by hypoxia exposure. The results suggested that HBO-PC induced hypoxic tolerance in mice via up-regulation of HIF-1α and its downstream genes. © 2008 Elsevier B.V. All rights reserved.

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ER -

Up-regulated HIF-1α is involved in the hypoxic tolerance induced by hyperbaric oxygen preconditioning

Abstract

ASJC Scopus Subject Areas

Keywords

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