TSLP-REGULATED GENE EXPRESSION SIGNATURE IN A PRECLINICAL MODEL OF CRLF2 B-ALL

Shannalee Martinez, Olivia Francis, Ruijun Su, Ineavely Baez, Ross Fisher, Christopher Morris, Xiaobing Zhang, Valeri Filippov, Sinisa Dovat, Kimberly Payne

Research output: Contribution to journalMeeting abstractpeer-review

Abstract

Background: Cure requires sustained treatment, but, failure to complete indicated treatment (treatment abandonment) occurs in up to one quarter of pediatric tuberculosis cases and half of pediatric oncology cases in some low- and middleincome settings (LMIS). Objectives: This systematic review assesses the design, delivery and outcomes of adherence interventions utilized in pediatric tuberculosis in LMIS, and evaluates the potential application of these interventions for pediatric oncology treatment adherence. Design/Method: A protocol was drafted in alignment with PRISMA standards and registered with PROSPERO. 412 reports published between 2003 and 2013 were identified from PubMed, COCHRANE bibliographies, hand-searching including of the grey literature, and expert consultation. 163 reports qualified for full-text review. Randomized control, quasi-experimental, and observational studies that utilized an intervention specific to treatment completion, adherence, prevention of refusal, or family-efficacy with a reported adherence-related outcome for pediatric-age populations (
Original languageAmerican English
JournalPediatric Blood Cancer
Volume61
Issue numberS1
DOIs
StatePublished - May 2014

Disciplines

  • Cellular and Molecular Physiology

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