TY - JOUR
T1 - Transplanting Mesenchymal Stem Cells for Treatment of Ischemic Stroke
AU - Wang, Fan
AU - Tang, Hailiang
AU - Zhu, Jianhong
AU - Zhang, John H.
N1 - Publisher Copyright:
© The Author(s) 2018.
PY - 2018/12/1
Y1 - 2018/12/1
N2 - Stroke is a major disease that leads to high mortality and morbidity. Given the ageing population and the potential risk factors, the prevalence of stroke and socioeconomic burden associated with stroke are expected to increase. During the past decade, both prophylactic and therapeutic strategies for stroke have made significant progress. However, current therapies still cannot adequately improve the outcomes of stroke and may not apply to all patients. One of the significant advances in modern medicine is cell-derived neurovascular regeneration and neuronal repair. Progress in stem cell biology has greatly contributed to ameliorating stroke-related brain injuries in preclinical studies and demonstrated clinical potential in stroke treatment. Mesenchymal stem cells (MSCs) have the differentiating potential of chondrocytes, adipocytes, and osteoblasts, and they have the ability to transdifferentiate into endothelial cells, glial cells, and neurons. Due to their great plasticity, MSCs have drawn much attention from the scientific community. This review will focus on MSCs, stem cells widely utilized in current medical research, and evaluate their effect and potential of improving outcomes in ischemic stroke.
AB - Stroke is a major disease that leads to high mortality and morbidity. Given the ageing population and the potential risk factors, the prevalence of stroke and socioeconomic burden associated with stroke are expected to increase. During the past decade, both prophylactic and therapeutic strategies for stroke have made significant progress. However, current therapies still cannot adequately improve the outcomes of stroke and may not apply to all patients. One of the significant advances in modern medicine is cell-derived neurovascular regeneration and neuronal repair. Progress in stem cell biology has greatly contributed to ameliorating stroke-related brain injuries in preclinical studies and demonstrated clinical potential in stroke treatment. Mesenchymal stem cells (MSCs) have the differentiating potential of chondrocytes, adipocytes, and osteoblasts, and they have the ability to transdifferentiate into endothelial cells, glial cells, and neurons. Due to their great plasticity, MSCs have drawn much attention from the scientific community. This review will focus on MSCs, stem cells widely utilized in current medical research, and evaluate their effect and potential of improving outcomes in ischemic stroke.
KW - Ischemic stroke
KW - MSCs
KW - stem cell replacement
KW - Humans
KW - Clinical Trials as Topic
KW - Neurons/cytology
KW - Neurogenesis
KW - Mesenchymal Stem Cells/cytology
KW - Animals
KW - Stroke/therapy
KW - Cell Differentiation
KW - Mesenchymal Stem Cell Transplantation
KW - Neovascularization, Physiologic
UR - http://www.scopus.com/inward/record.url?scp=85058762542&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85058762542&partnerID=8YFLogxK
UR - https://www.mendeley.com/catalogue/333258be-d399-3507-bcf2-fea7b2d158ef/
U2 - 10.1177/0963689718795424
DO - 10.1177/0963689718795424
M3 - Article
C2 - 30251564
SN - 0963-6897
VL - 27
SP - 1825
EP - 1834
JO - Cell Transplantation
JF - Cell Transplantation
IS - 12
ER -