Translational evidence for increased central amygdala IL-6 activity in alcohol dependence

Celsey M. St. Onge; Chloe Erikson; Bryan Cruz; Vittoria Borgonetti; Joel G. Hashimoto; Jessica A. Cucinello-Ragland; Taylor Fitzpatrick-Schmidt; Larry Rodriguez; Sophia Khom; Michela Palmisano; Roman Vlkolinsky; Christopher S. Oleata; Tali Nadav; Nihal A. Salem; Scott Edwards; R. Dayne Mayfield; Marina Guizzetti; Amanda J. Roberts; Michal Bajo; Marisa Roberto

doi:10.1186/s12974-026-03868-2

Translational evidence for increased central amygdala IL-6 activity in alcohol dependence

Celsey M. St. Onge
, Chloe Erikson
, Bryan Cruz
, Vittoria Borgonetti
, Joel G. Hashimoto
, Jessica A. Cucinello-Ragland
, Taylor Fitzpatrick-Schmidt
, Larry Rodriguez
, Sophia Khom
, Michela Palmisano
, Roman Vlkolinsky
, Christopher S. Oleata
, Tali Nadav
, Nihal A. Salem
, Scott Edwards
, R. Dayne Mayfield
, Marina Guizzetti
, Amanda J. Roberts
, Michal Bajo
, Marisa Roberto

Research output: Contribution to journal › Article › peer-review

Original language	English
Article number	211
Journal	Journal of neuroinflammation
Volume	23
Issue number	1
DOIs	https://doi.org/10.1186/s12974-026-03868-2
State	Published - Dec 2026
Externally published	Yes

ASJC Scopus Subject Areas

General Neuroscience
Immunology
Neurology
Cellular and Molecular Neuroscience

Keywords

Brain
Cytokine
Electrophysiology
Ethanol
Gene expression
Human
Mouse
Neuroimmune
RNA-seq
RNAscope

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10.1186/s12974-026-03868-2

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St. Onge, C. M., Erikson, C., Cruz, B., Borgonetti, V., Hashimoto, J. G., Cucinello-Ragland, J. A., Fitzpatrick-Schmidt, T., Rodriguez, L., Khom, S., Palmisano, M., Vlkolinsky, R., Oleata, C. S., Nadav, T., Salem, N. A., Edwards, S., Mayfield, R. D., Guizzetti, M., Roberts, A. J., Bajo, M., & Roberto, M. (2026). Translational evidence for increased central amygdala IL-6 activity in alcohol dependence. Journal of neuroinflammation, 23(1), Article 211. https://doi.org/10.1186/s12974-026-03868-2

St. Onge, CM, Erikson, C, Cruz, B, Borgonetti, V, Hashimoto, JG, Cucinello-Ragland, JA, Fitzpatrick-Schmidt, T, Rodriguez, L, Khom, S, Palmisano, M, Vlkolinsky, R, Oleata, CS, Nadav, T, Salem, NA, Edwards, S, Mayfield, RD, Guizzetti, M, Roberts, AJ, Bajo, M & Roberto, M 2026, 'Translational evidence for increased central amygdala IL-6 activity in alcohol dependence', Journal of neuroinflammation, vol. 23, no. 1, 211. https://doi.org/10.1186/s12974-026-03868-2

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doi = "10.1186/s12974-026-03868-2",

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AU - St. Onge, Celsey M.

AU - Erikson, Chloe

AU - Cruz, Bryan

AU - Borgonetti, Vittoria

AU - Hashimoto, Joel G.

AU - Cucinello-Ragland, Jessica A.

AU - Fitzpatrick-Schmidt, Taylor

AU - Rodriguez, Larry

AU - Khom, Sophia

AU - Palmisano, Michela

AU - Vlkolinsky, Roman

AU - Oleata, Christopher S.

AU - Nadav, Tali

AU - Salem, Nihal A.

AU - Edwards, Scott

AU - Mayfield, R. Dayne

AU - Guizzetti, Marina

AU - Roberts, Amanda J.

AU - Bajo, Michal

AU - Roberto, Marisa

N1 - Publisher Copyright: © The Author(s) 2026.

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Y1 - 2026/12

KW - Brain

KW - Cytokine

KW - Electrophysiology

KW - Ethanol

KW - Gene expression

KW - Human

KW - Mouse

KW - Neuroimmune

KW - RNA-seq

KW - RNAscope

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JO - Journal of neuroinflammation

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ER -

Translational evidence for increased central amygdala IL-6 activity in alcohol dependence

ASJC Scopus Subject Areas

Keywords

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