Transient receptor potential ion channel TRPM2 promotes AML proliferation and survival through modulation of mitochondrial function, ROS, and autophagy

Shu jen Chen; Lei Bao; Kerry Keefer; Santhanam Shanmughapriya; Longgui Chen; John Lee; Ju Fang Wang; Xue Qian Zhang; Iwona Hirschler-Laszkiewicz; Salim Merali; Carmen Merali; Yuka Imamura; Sinisa Dovat; Muniswamy Madesh; Joseph Y. Cheung; Hong Gang Wang; Barbara A. Miller

doi:10.1038/s41419-020-2454-8

Transient receptor potential ion channel TRPM2 promotes AML proliferation and survival through modulation of mitochondrial function, ROS, and autophagy

Shu jen Chen
, Lei Bao
, Kerry Keefer
, Santhanam Shanmughapriya
, Longgui Chen
, John Lee
, Ju Fang Wang
, Xue Qian Zhang
, Iwona Hirschler-Laszkiewicz
, Salim Merali
, Carmen Merali
, Yuka Imamura
, Sinisa Dovat
, Muniswamy Madesh
, Joseph Y. Cheung
, Hong Gang Wang
, Barbara A. Miller

Research output: Contribution to journal › Article › peer-review

Original language	English
Article number	247
Journal	Cell Death and Disease
Volume	11
Issue number	4
DOIs	https://doi.org/10.1038/s41419-020-2454-8
State	Published - Apr 20 2020
Externally published	Yes

ASJC Scopus Subject Areas

Immunology
Cellular and Molecular Neuroscience
Cell Biology
Cancer Research

Keywords

Reactive Oxygen Species/metabolism
Humans
Leukemia, Myeloid, Acute/drug therapy
Autophagy/drug effects
Transient Receptor Potential Channels/metabolism
Cell Survival/drug effects
Membrane Potential, Mitochondrial/drug effects
Oxidative Stress/drug effects
TRPM Cation Channels/drug effects
Mitochondria/drug effects
Cell Line, Tumor
Cell Proliferation/drug effects
Doxorubicin/pharmacology

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Chen, S. J., Bao, L., Keefer, K., Shanmughapriya, S., Chen, L., Lee, J., Wang, J. F., Zhang, X. Q., Hirschler-Laszkiewicz, I., Merali, S., Merali, C., Imamura, Y., Dovat, S., Madesh, M., Cheung, J. Y., Wang, H. G., & Miller, B. A. (2020). Transient receptor potential ion channel TRPM2 promotes AML proliferation and survival through modulation of mitochondrial function, ROS, and autophagy. Cell Death and Disease, 11(4), Article 247. https://doi.org/10.1038/s41419-020-2454-8

Chen, SJ, Bao, L, Keefer, K, Shanmughapriya, S, Chen, L, Lee, J, Wang, JF, Zhang, XQ, Hirschler-Laszkiewicz, I, Merali, S, Merali, C, Imamura, Y, Dovat, S, Madesh, M, Cheung, JY, Wang, HG & Miller, BA 2020, 'Transient receptor potential ion channel TRPM2 promotes AML proliferation and survival through modulation of mitochondrial function, ROS, and autophagy', Cell Death and Disease, vol. 11, no. 4, 247. https://doi.org/10.1038/s41419-020-2454-8

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AU - Chen, Shu jen

AU - Bao, Lei

AU - Keefer, Kerry

AU - Shanmughapriya, Santhanam

AU - Chen, Longgui

AU - Lee, John

AU - Wang, Ju Fang

AU - Zhang, Xue Qian

AU - Hirschler-Laszkiewicz, Iwona

AU - Merali, Salim

AU - Merali, Carmen

AU - Imamura, Yuka

AU - Dovat, Sinisa

AU - Madesh, Muniswamy

AU - Cheung, Joseph Y.

AU - Wang, Hong Gang

AU - Miller, Barbara A.

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KW - Leukemia, Myeloid, Acute/drug therapy

KW - Autophagy/drug effects

KW - Transient Receptor Potential Channels/metabolism

KW - Cell Survival/drug effects

KW - Membrane Potential, Mitochondrial/drug effects

KW - Oxidative Stress/drug effects

KW - TRPM Cation Channels/drug effects

KW - Mitochondria/drug effects

KW - Cell Line, Tumor

KW - Cell Proliferation/drug effects

KW - Doxorubicin/pharmacology

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Transient receptor potential ion channel TRPM2 promotes AML proliferation and survival through modulation of mitochondrial function, ROS, and autophagy

ASJC Scopus Subject Areas

Keywords

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