Transgenic Overexpression of Ephrin B1 in Bone Cells Promotes Bone Formation and an Anabolic Response to Mechanical Loading in Mice

Shaohong Cheng; Chandrasekhar Kesavan; Subburaman Mohan; Xuezhong Qin; Catrina M. Alarcon; Jon Wergedal; Weirong Xing

doi:10.1371/journal.pone.0069051

Transgenic Overexpression of Ephrin B1 in Bone Cells Promotes Bone Formation and an Anabolic Response to Mechanical Loading in Mice

Shaohong Cheng
, Chandrasekhar Kesavan
, Subburaman Mohan
, Xuezhong Qin
, Catrina M. Alarcon
, Jon Wergedal
, Weirong Xing

Research output: Contribution to journal › Article › peer-review

Original language	English
Article number	e69051
Journal	PLoS ONE
Volume	8
Issue number	7
DOIs	https://doi.org/10.1371/journal.pone.0069051
State	Published - Jul 11 2013

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title = "Transgenic Overexpression of Ephrin B1 in Bone Cells Promotes Bone Formation and an Anabolic Response to Mechanical Loading in Mice",

author = "Shaohong Cheng and Chandrasekhar Kesavan and Subburaman Mohan and Xuezhong Qin and Alarcon, \{Catrina M.\} and Jon Wergedal and Weirong Xing",

note = "To test if ephrin B1 overexpression enhances bone mass, we generated transgenic mice overexpressing ephrin B1 under the control of a 3.6 kb rat collagen 1A1 promoter (Col3.6-Tg). Col3.6-Tg mice express 6-, 12- and 14-fold greater levels of full-length ephrin B1 protein in bone marrow stromal cells, calvarial osteoblasts, and osteoclasts, respectively.",

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AU - Cheng, Shaohong

AU - Kesavan, Chandrasekhar

AU - Mohan, Subburaman

AU - Qin, Xuezhong

AU - Alarcon, Catrina M.

AU - Wergedal, Jon

AU - Xing, Weirong

N1 - To test if ephrin B1 overexpression enhances bone mass, we generated transgenic mice overexpressing ephrin B1 under the control of a 3.6 kb rat collagen 1A1 promoter (Col3.6-Tg). Col3.6-Tg mice express 6-, 12- and 14-fold greater levels of full-length ephrin B1 protein in bone marrow stromal cells, calvarial osteoblasts, and osteoclasts, respectively.

PY - 2013/7/11

Y1 - 2013/7/11

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UR - https://www.scopus.com/pages/publications/84880058088#tab=citedBy

U2 - 10.1371/journal.pone.0069051

DO - 10.1371/journal.pone.0069051

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SN - 1932-6203

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JO - PLoS ONE

JF - PLoS ONE

IS - 7

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Transgenic Overexpression of Ephrin B1 in Bone Cells Promotes Bone Formation and an Anabolic Response to Mechanical Loading in Mice

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