Transferrin receptor 1-mediated iron uptake regulates bone mass in mice via osteoclast mitochondria and cytoskeleton

Bhaba K. Das; Lei Wang; Toshifumi Fujiwara; Jian Zhou; Nukhet Aykin-Burns; Kimberly J. Krager; Renny Lan; Samuel G. Mackintosh; Ricky Edmondson; Michael L. Jennings; Xiaofang Wang; Jian Q. Feng; Tomasa Barrientos; Jyoti Gogoi; Aarthi Kannan; Ling Gao; Weirong Xing; Subburaman Mohan; Haibo Zhao

doi:10.7554/eLife.73539

Transferrin receptor 1-mediated iron uptake regulates bone mass in mice via osteoclast mitochondria and cytoskeleton

Bhaba K. Das
, Lei Wang
, Toshifumi Fujiwara
, Jian Zhou
, Nukhet Aykin-Burns
, Kimberly J. Krager
, Renny Lan
, Samuel G. Mackintosh
, Ricky Edmondson
, Michael L. Jennings
, Xiaofang Wang
, Jian Q. Feng
, Tomasa Barrientos
, Jyoti Gogoi
, Aarthi Kannan
, Ling Gao
, Weirong Xing
, Subburaman Mohan
, Haibo Zhao

Research output: Contribution to journal › Article › peer-review

Original language	English
Article number	e73539
Journal	eLife
Volume	11
DOIs	https://doi.org/10.7554/eLife.73539
State	Published - Jun 2022
Externally published	Yes

ASJC Scopus Subject Areas

General Neuroscience
General Biochemistry,Genetics and Molecular Biology
General Immunology and Microbiology

Keywords

Osteoclasts/metabolism
Animals
Mitochondria/metabolism
Receptors, Transferrin/genetics
Bone Resorption/pathology
Cytoskeleton/metabolism
Female
Iron/metabolism
Mice
Mice, Knockout

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10.7554/eLife.73539

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Das, B. K., Wang, L., Fujiwara, T., Zhou, J., Aykin-Burns, N., Krager, K. J., Lan, R., Mackintosh, S. G., Edmondson, R., Jennings, M. L., Wang, X., Feng, J. Q., Barrientos, T., Gogoi, J., Kannan, A., Gao, L., Xing, W., Mohan, S., & Zhao, H. (2022). Transferrin receptor 1-mediated iron uptake regulates bone mass in mice via osteoclast mitochondria and cytoskeleton. eLife, 11, Article e73539. https://doi.org/10.7554/eLife.73539

Das, BK, Wang, L, Fujiwara, T, Zhou, J, Aykin-Burns, N, Krager, KJ, Lan, R, Mackintosh, SG, Edmondson, R, Jennings, ML, Wang, X, Feng, JQ, Barrientos, T, Gogoi, J, Kannan, A, Gao, L, Xing, W , Mohan, S & Zhao, H 2022, 'Transferrin receptor 1-mediated iron uptake regulates bone mass in mice via osteoclast mitochondria and cytoskeleton', eLife, vol. 11, e73539. https://doi.org/10.7554/eLife.73539

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keywords = "Osteoclasts/metabolism, Animals, Mitochondria/metabolism, Receptors, Transferrin/genetics, Bone Resorption/pathology, Cytoskeleton/metabolism, Female, Iron/metabolism, Mice, Mice, Knockout",

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year = "2022",

month = jun,

doi = "10.7554/eLife.73539",

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AU - Das, Bhaba K.

AU - Wang, Lei

AU - Fujiwara, Toshifumi

AU - Zhou, Jian

AU - Aykin-Burns, Nukhet

AU - Krager, Kimberly J.

AU - Lan, Renny

AU - Mackintosh, Samuel G.

AU - Edmondson, Ricky

AU - Jennings, Michael L.

AU - Wang, Xiaofang

AU - Feng, Jian Q.

AU - Barrientos, Tomasa

AU - Gogoi, Jyoti

AU - Kannan, Aarthi

AU - Gao, Ling

AU - Xing, Weirong

AU - Mohan, Subburaman

AU - Zhao, Haibo

PY - 2022/6

Y1 - 2022/6

KW - Osteoclasts/metabolism

KW - Animals

KW - Mitochondria/metabolism

KW - Receptors, Transferrin/genetics

KW - Bone Resorption/pathology

KW - Cytoskeleton/metabolism

KW - Female

KW - Iron/metabolism

KW - Mice

KW - Mice, Knockout

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AN - SCOPUS:85134616556

SN - 2050-084X

VL - 11

JO - eLife

JF - eLife

M1 - e73539

ER -

Transferrin receptor 1-mediated iron uptake regulates bone mass in mice via osteoclast mitochondria and cytoskeleton

ASJC Scopus Subject Areas

Keywords

Access to Document

OpenUrl availability

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