TY - JOUR
T1 - Trace element levels in drinking water and cognitive function among elderly Chinese
AU - Emsley, Christine L.
AU - Gao, Sujuan
AU - Li, Yiming
AU - Liang, Chaoke
AU - Ji, Rongdi
AU - Hall, Kathleen S.
AU - Cao, Jingxiang
AU - Ma, Feng
AU - Wu, Yunpeng
AU - Ying, Po
AU - Zhang, Yan
AU - Sun, Shuzhuang
AU - Unverzagt, Frederick W.
AU - Slemenda, Charles W.
AU - Hendrie, Hugh C.
N1 - Funding Information:
This work was supported in part by National Institute of Aging grant P30 AG10133 and a grant from Eli Lilly and Company (Indianapolis, Indiana).
PY - 2000/5/1
Y1 - 2000/5/1
N2 - The relation between trace element levels in drinking water and cognitive function was investigated in a population-based study of elderly residents (n = 1,016) in rural China in 1996-1997. Cognitive function was measured using a Chinese translation of the Community Screening Interview for Dementia. A mixed effects model was used to evaluate the effect of each of the elements on cognitive function while adjusting for age, sex, and educational level. Several of the elements examined had a significant effect on cognitive function when they were assessed in a univariate context. However, after adjustment for other elements, many of these results were not significant. There was a significant quadratic effect for calcium and a significant zinc-cadmium interaction. Cognitive function increased with calcium level up to a certain point and then decreased as calcium continued to increase. Zinc showed a positive relation with cognitive function at low cadmium levels but a negative relation at high levels.
AB - The relation between trace element levels in drinking water and cognitive function was investigated in a population-based study of elderly residents (n = 1,016) in rural China in 1996-1997. Cognitive function was measured using a Chinese translation of the Community Screening Interview for Dementia. A mixed effects model was used to evaluate the effect of each of the elements on cognitive function while adjusting for age, sex, and educational level. Several of the elements examined had a significant effect on cognitive function when they were assessed in a univariate context. However, after adjustment for other elements, many of these results were not significant. There was a significant quadratic effect for calcium and a significant zinc-cadmium interaction. Cognitive function increased with calcium level up to a certain point and then decreased as calcium continued to increase. Zinc showed a positive relation with cognitive function at low cadmium levels but a negative relation at high levels.
KW - Aged
KW - Cadmium
KW - Calcium
KW - Cognition
KW - Trace elements
KW - Water supply
KW - Zinc
UR - https://www.scopus.com/pages/publications/18344403707
UR - https://www.scopus.com/pages/publications/18344403707#tab=citedBy
UR - https://www.mendeley.com/catalogue/4c4ab2db-2c0f-38da-ace1-e3d13c313d67/
U2 - 10.1093/oxfordjournals.aje.a010295
DO - 10.1093/oxfordjournals.aje.a010295
M3 - Article
C2 - 10791564
SN - 0002-9262
VL - 151
SP - 913
EP - 920
JO - American Journal of Epidemiology
JF - American Journal of Epidemiology
IS - 9
ER -