Toxicant Loss of Immune Tolerance, Neurologic Disease, and Nutritional Strategies

This paper reviews immunology models of chemical tolerance and the role they may play with the pathogenesis of neurological autoimmune and neurodegenerative disease and how we may be able to reduce the impacts of these adverse reactions with various nutritional applications. The immune model of chemical tolerance describes how trace amounts of exposures to various chemicals commonly found within our environment lead to exaggerated immune responses turning on the cascade of immune dysregulation and systemic inflammation leading to neurological disease. Immune chemical tolerance is maintained by healthy integration of various immune cells that can be disrupted from toxicant exposure, chronic stress physiology, blood-brain barrier compromise, intestinal barrier compromise, hormone imbalances, antigenic models, oxidative stress models, and various mechanisms that induce loss of healthy immune integration. These mechanisms themselves have been shown to have the ability to be manipulated and modulated with various nutritional applications. With an increasing epidemic of toxicant load and virtually no conventional or pharmaceutical strategies to decrease their impacts on human systems evidence-based consideration leads us to the potential role of various natural compounds that exhibit activity that can decrease the expression NF-kappaB, optimize glutathione redox systems, improve barrier system impermeability, and support regulatory T-cell activity all which is essential to improve chemical immune tolerance environmental toxicants.