TOP1 inhibition induces bifurcated JNK/MYC signaling that dictates cancer cell sensitivity

Qizhi Liu, Stacey Chung, Michael M. Murata, Bingchen Han, Bowen Gao, Maoqi Zhang, Tian Yu Lee, Evgeny Chirshev, Juli Unternaehrer, Hisashi Tanaka, Armando E. Giuliano, Yukun Cui, Xiaojiang Cui

Research output: Contribution to journalArticlepeer-review

Original languageEnglish
Pages (from-to)4203-4218
Number of pages16
JournalInternational Journal of Biological Sciences
Volume18
Issue number10
DOIs
StatePublished - Jun 27 2022

ASJC Scopus Subject Areas

  • Ecology, Evolution, Behavior and Systematics
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Developmental Biology
  • Cell Biology

Keywords

  • ATR
  • JNK
  • MYC
  • TOP1 inhibitor
  • Triple-negative Breast Cancer
  • Cell Proliferation
  • Humans
  • Signal Transduction/genetics
  • Animals
  • Triple Negative Breast Neoplasms/drug therapy
  • Cell Line, Tumor
  • Proto-Oncogene Proteins c-myc/genetics
  • Topotecan/pharmacology
  • DNA Topoisomerases, Type I/metabolism
  • Mice

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