TY - JOUR
T1 - The use of naltrexone in the management of severe generalized pruritus in biliary atresia
T2 - Report of a case
AU - Chang, Yuchi
AU - Golkar, Linda
N1 - Pediatr Dermatol. 2008 May-Jun;25(3):403-4. doi: 10.1111/j.1525-1470.2008.00699.x. Case Reports
PY - 2008/5
Y1 - 2008/5
N2 - Generalized pruritus secondary to cholestasis is a difficult dermatologic condition to treat. We present a case of a 17-month-old child with congenital biliary atresia with generalized pruritus refractory to treatment with oral antihistamines, topical steroids, cholestyramine, and rifampin but improved remarkably with the addition of naltrexone. Naltrexone is a well-tolerated medication with little adverse effects. We believe that naltrexone may be an effective adjuvant treatment in the management of cholestatic pruritus in the pediatric population.
AB - Generalized pruritus secondary to cholestasis is a difficult dermatologic condition to treat. We present a case of a 17-month-old child with congenital biliary atresia with generalized pruritus refractory to treatment with oral antihistamines, topical steroids, cholestyramine, and rifampin but improved remarkably with the addition of naltrexone. Naltrexone is a well-tolerated medication with little adverse effects. We believe that naltrexone may be an effective adjuvant treatment in the management of cholestatic pruritus in the pediatric population.
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U2 - 10.1111/j.1525-1470.2008.00699.x
DO - 10.1111/j.1525-1470.2008.00699.x
M3 - Article
C2 - 18577062
SN - 0736-8046
VL - 25
SP - 403
EP - 404
JO - Pediatric Dermatology
JF - Pediatric Dermatology
IS - 3
ER -