The Somatosensory Evoked Potential Predicts Neurologic Deficits and Serotonergic Pathochemistry After Spinal Distraction Injury in Experimental Scoliosis

S. K. Salzman; K. W. Dabney; A. A. Mendez; J. T. Beauchamp; J. C. Daley; G. M. Freeman; A. Fonseca; E. B. Ingersoll; A. L. Beckman; W. P. Bunnell

doi:10.1089/neu.1988.5.173

The Somatosensory Evoked Potential Predicts Neurologic Deficits and Serotonergic Pathochemistry After Spinal Distraction Injury in Experimental Scoliosis

S. K. Salzman, K. W. Dabney, A. A. Mendez, J. T. Beauchamp, J. C. Daley, G. M. Freeman, A. Fonseca, E. B. Ingersoll, A. L. Beckman, W. P. Bunnell

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Abstract

The validity of the somatosensory evoked potential as an intraoperative spinal cord monitor was evaluated in an experimental model of scoliosis in the rat and a Harrington distraction model of injury. Under these conditions, it was found that any change in latency or amplitude of the major negative wave above a certain level was a significant predictor of an adverse neurologic outcome. Changes in latency of 4% or greater and changes in amplitude of 50% or greater were unequivocal indicators of spinal cord injury. Postmortem analyses of the spinal neurotransmitter serotonin revealed that apparent false-positive results of the SEP were, in fact, true-positive results.

Original language	English
Pages (from-to)	173-186
Number of pages	14
Journal	Journal of Neurotrauma
Volume	5
Issue number	3
DOIs	https://doi.org/10.1089/neu.1988.5.173
State	Published - 1988

ASJC Scopus Subject Areas

Clinical Neurology

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Salzman, S. K., Dabney, K. W., Mendez, A. A., Beauchamp, J. T., Daley, J. C., Freeman, G. M., Fonseca, A., Ingersoll, E. B., Beckman, A. L., & Bunnell, W. P. (1988). The Somatosensory Evoked Potential Predicts Neurologic Deficits and Serotonergic Pathochemistry After Spinal Distraction Injury in Experimental Scoliosis. Journal of Neurotrauma, 5(3), 173-186. https://doi.org/10.1089/neu.1988.5.173

Salzman, SK, Dabney, KW, Mendez, AA, Beauchamp, JT, Daley, JC, Freeman, GM, Fonseca, A, Ingersoll, EB, Beckman, AL & Bunnell, WP 1988, 'The Somatosensory Evoked Potential Predicts Neurologic Deficits and Serotonergic Pathochemistry After Spinal Distraction Injury in Experimental Scoliosis', Journal of Neurotrauma, vol. 5, no. 3, pp. 173-186. https://doi.org/10.1089/neu.1988.5.173

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The Somatosensory Evoked Potential Predicts Neurologic Deficits and Serotonergic Pathochemistry After Spinal Distraction Injury in Experimental Scoliosis

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