TY - JOUR
T1 - The role of Monte Carlo simulation in understanding the performance of proton computed tomography
AU - Dedes, George
AU - Dickmann, Jannis
AU - Giacometti, Valentina
AU - Rit, Simon
AU - Krah, Nils
AU - Meyer, Sebastian
AU - Bashkirov, Vladimir
AU - Schulte, Reinhard
AU - Johnson, Robert P.
AU - Parodi, Katia
AU - Landry, Guillaume
N1 - Publisher Copyright:
© 2020
PY - 2022/2
Y1 - 2022/2
N2 - Proton computed tomography (pCT) is a promising tomographic imaging modality allowing direct reconstruction of proton relative stopping power (RSP) required for proton therapy dose calculation. In this review article, we aim at highlighting the role of Monte Carlo (MC) simulation in pCT studies. After describing the requirements for performing proton computed tomography and the various pCT scanners actively used in recent research projects, we present an overview of available MC simulation platforms. The use of MC simulations in the scope of investigations of image reconstruction, and for the evaluation of optimal RSP accuracy, precision and spatial resolution omitting detector effects is then described. In the final sections of the review article, we present specific applications of realistic MC simulations of an existing pCT scanner prototype, which we describe in detail.
AB - Proton computed tomography (pCT) is a promising tomographic imaging modality allowing direct reconstruction of proton relative stopping power (RSP) required for proton therapy dose calculation. In this review article, we aim at highlighting the role of Monte Carlo (MC) simulation in pCT studies. After describing the requirements for performing proton computed tomography and the various pCT scanners actively used in recent research projects, we present an overview of available MC simulation platforms. The use of MC simulations in the scope of investigations of image reconstruction, and for the evaluation of optimal RSP accuracy, precision and spatial resolution omitting detector effects is then described. In the final sections of the review article, we present specific applications of realistic MC simulations of an existing pCT scanner prototype, which we describe in detail.
KW - Monte Carlo simulation
KW - Proton computed tomography
KW - Proton therapy
KW - Relative proton stopping power
UR - http://www.scopus.com/inward/record.url?scp=85089295217&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85089295217&partnerID=8YFLogxK
U2 - 10.1016/j.zemedi.2020.06.006
DO - 10.1016/j.zemedi.2020.06.006
M3 - Review article
C2 - 32798033
SN - 0939-3889
VL - 32
SP - 23
EP - 38
JO - Zeitschrift fur Medizinische Physik
JF - Zeitschrift fur Medizinische Physik
IS - 1
ER -