The Relative Biological Effectiveness of Attenuated Protons

James B. Robertson; William C. Glisson; John O. Archambeau; George B. Coutrakan; Daniel W. Miller; Michael F. Moyers; Jeffrey F. Siebers; James M. Slater; John F. Dicello

doi:10.1007/978-1-4615-2916-3_18

The Relative Biological Effectiveness of Attenuated Protons

James B. Robertson, William C. Glisson, John O. Archambeau, George B. Coutrakan, Daniel W. Miller, Michael F. Moyers, Jeffrey F. Siebers, James M. Slater, John F. Dicello

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

 The 250 MeV Synchrotron at Loma Linda University Medical Center has been in operation since October 1990. In this paper we will report the data collected for survival of V79 cells suspended in gelatin exposed to 100 MeV protons that are attenuated with varying thicknesses of polycarbonate plastic. The measured RBE for single-cell killing ranges from 1.05 to 1.20 as the protons are reduced in energy from 64 MeV. Survival profiles show that this RBE effect will result in a 2.5 fold difference in cell survival between high and low energy protons at a dose of 1000 cGy. Correspondingly, the microdosimetric spectra measured in the same beam offer a quantitative explanation for the observed variation in RBE. Both the biological and the microdosimetric results suggest that the number of intermediate lineal energy events increase as the protons are attenuated. These results suggest that while shielding will reduce the total absorbed dose due to a solar proton event, it might not be equally effective in reducing the radiobiological effect of the exposure.
 
 

Original language	American English
Title of host publication	Biological Effects and Physics of Solar and Galactic Cosmic Radiation
DOIs	https://doi.org/10.1007/978-1-4615-2916-3_18
State	Published - Jan 1 1993

Keywords

Relative Biological Effectiveness
Solar Proton Event
Radiation Biology
Solar Particle Event
Galactic Cosmic Radiation

Disciplines

Radiochemistry

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title = "The Relative Biological Effectiveness of Attenuated Protons",

abstract = " The 250 MeV Synchrotron at Loma Linda University Medical Center has been in operation since October 1990. In this paper we will report the data collected for survival of V79 cells suspended in gelatin exposed to 100 MeV protons that are attenuated with varying thicknesses of polycarbonate plastic. The measured RBE for single-cell killing ranges from 1.05 to 1.20 as the protons are reduced in energy from 64 MeV. Survival profiles show that this RBE effect will result in a 2.5 fold difference in cell survival between high and low energy protons at a dose of 1000 cGy. Correspondingly, the microdosimetric spectra measured in the same beam offer a quantitative explanation for the observed variation in RBE. Both the biological and the microdosimetric results suggest that the number of intermediate lineal energy events increase as the protons are attenuated. These results suggest that while shielding will reduce the total absorbed dose due to a solar proton event, it might not be equally effective in reducing the radiobiological effect of the exposure. ",

keywords = "Relative Biological Effectiveness, Solar Proton Event, Radiation Biology, Solar Particle Event, Galactic Cosmic Radiation",

author = "Robertson, {James B.} and Glisson, {William C.} and Archambeau, {John O.} and Coutrakan, {George B.} and Miller, {Daniel W.} and Moyers, {Michael F.} and Siebers, {Jeffrey F.} and Slater, {James M.} and Dicello, {John F.}",

year = "1993",

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doi = "10.1007/978-1-4615-2916-3_18",

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T1 - The Relative Biological Effectiveness of Attenuated Protons

AU - Robertson, James B.

AU - Glisson, William C.

AU - Archambeau, John O.

AU - Coutrakan, George B.

AU - Miller, Daniel W.

AU - Moyers, Michael F.

AU - Siebers, Jeffrey F.

AU - Slater, James M.

AU - Dicello, John F.

PY - 1993/1/1

Y1 - 1993/1/1

N2 - The 250 MeV Synchrotron at Loma Linda University Medical Center has been in operation since October 1990. In this paper we will report the data collected for survival of V79 cells suspended in gelatin exposed to 100 MeV protons that are attenuated with varying thicknesses of polycarbonate plastic. The measured RBE for single-cell killing ranges from 1.05 to 1.20 as the protons are reduced in energy from 64 MeV. Survival profiles show that this RBE effect will result in a 2.5 fold difference in cell survival between high and low energy protons at a dose of 1000 cGy. Correspondingly, the microdosimetric spectra measured in the same beam offer a quantitative explanation for the observed variation in RBE. Both the biological and the microdosimetric results suggest that the number of intermediate lineal energy events increase as the protons are attenuated. These results suggest that while shielding will reduce the total absorbed dose due to a solar proton event, it might not be equally effective in reducing the radiobiological effect of the exposure.

AB - The 250 MeV Synchrotron at Loma Linda University Medical Center has been in operation since October 1990. In this paper we will report the data collected for survival of V79 cells suspended in gelatin exposed to 100 MeV protons that are attenuated with varying thicknesses of polycarbonate plastic. The measured RBE for single-cell killing ranges from 1.05 to 1.20 as the protons are reduced in energy from 64 MeV. Survival profiles show that this RBE effect will result in a 2.5 fold difference in cell survival between high and low energy protons at a dose of 1000 cGy. Correspondingly, the microdosimetric spectra measured in the same beam offer a quantitative explanation for the observed variation in RBE. Both the biological and the microdosimetric results suggest that the number of intermediate lineal energy events increase as the protons are attenuated. These results suggest that while shielding will reduce the total absorbed dose due to a solar proton event, it might not be equally effective in reducing the radiobiological effect of the exposure.

KW - Relative Biological Effectiveness

KW - Solar Proton Event

KW - Radiation Biology

KW - Solar Particle Event

KW - Galactic Cosmic Radiation

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DO - 10.1007/978-1-4615-2916-3_18

M3 - Chapter

BT - Biological Effects and Physics of Solar and Galactic Cosmic Radiation

ER -

The Relative Biological Effectiveness of Attenuated Protons

Abstract

Keywords

Disciplines

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