The nonconserved hydrophilic loop domain of presenilin (PS) is not required for PS endoproteolysis or enhanced Aβ42 production mediated by familial early onset Alzheimer's disease-linked PS variants

Carlos A. Saura, Taisuke Tomita, Salvador Soriano, Masaaki Takahashi, Jae Yoon Leem, Toshiyuki Honda, Edward H. Koo, Takeshi Iwatsubo, Gopal Thinakaranf

Research output: Contribution to journalArticlepeer-review

Original languageEnglish
Pages (from-to)17136-17142
Number of pages7
JournalJournal of Biological Chemistry
Volume275
Issue number22
DOIs
StatePublished - Jun 2 2000
Externally publishedYes

ASJC Scopus Subject Areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Keywords

  • Presenilin-2
  • Presenilin-1
  • Humans
  • Peptide Fragments/biosynthesis
  • DNA Primers
  • Hydrolysis
  • Receptors, Notch
  • Animals
  • Membrane Proteins/chemistry
  • Base Sequence
  • Age of Onset
  • Protein Conformation
  • Mice
  • Protein Processing, Post-Translational
  • Amyloid beta-Peptides/biosynthesis
  • Alzheimer Disease/metabolism
  • COS Cells

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