The nonconserved hydrophilic loop domain of presenilin (PS) is not required for PS endoproteolysis or enhanced Aβ42 production mediated by familial early onset Alzheimer's disease-linked PS variants

Carlos A. Saura; Taisuke Tomita; Salvador Soriano; Masaaki Takahashi; Jae Yoon Leem; Toshiyuki Honda; Edward H. Koo; Takeshi Iwatsubo; Gopal Thinakaranf

doi:10.1074/jbc.M909624199

The nonconserved hydrophilic loop domain of presenilin (PS) is not required for PS endoproteolysis or enhanced Aβ42 production mediated by familial early onset Alzheimer's disease-linked PS variants

Carlos A. Saura, Taisuke Tomita, Salvador Soriano, Masaaki Takahashi, Jae Yoon Leem, Toshiyuki Honda, Edward H. Koo, Takeshi Iwatsubo, Gopal Thinakaranf

Research output: Contribution to journal › Article › peer-review

Original language	English
Pages (from-to)	17136-17142
Number of pages	7
Journal	Journal of Biological Chemistry
Volume	275
Issue number	22
DOIs	https://doi.org/10.1074/jbc.M909624199
State	Published - Jun 2 2000

ASJC Scopus Subject Areas

Biochemistry
Molecular Biology
Cell Biology

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Saura, C. A., Tomita, T., Soriano, S., Takahashi, M., Leem, J. Y., Honda, T., Koo, E. H., Iwatsubo, T., & Thinakaranf, G. (2000). The nonconserved hydrophilic loop domain of presenilin (PS) is not required for PS endoproteolysis or enhanced Aβ42 production mediated by familial early onset Alzheimer's disease-linked PS variants. Journal of Biological Chemistry, 275(22), 17136-17142. https://doi.org/10.1074/jbc.M909624199

The nonconserved hydrophilic loop domain of presenilin (PS) is not required for PS endoproteolysis or enhanced Aβ42 production mediated by familial early onset Alzheimer's disease-linked PS variants. / Saura, Carlos A.; Tomita, Taisuke; Soriano, Salvador et al.
In: Journal of Biological Chemistry, Vol. 275, No. 22, 02.06.2000, p. 17136-17142.

Research output: Contribution to journal › Article › peer-review

Saura, CA, Tomita, T, Soriano, S, Takahashi, M, Leem, JY, Honda, T, Koo, EH, Iwatsubo, T & Thinakaranf, G 2000, 'The nonconserved hydrophilic loop domain of presenilin (PS) is not required for PS endoproteolysis or enhanced Aβ42 production mediated by familial early onset Alzheimer's disease-linked PS variants', Journal of Biological Chemistry, vol. 275, no. 22, pp. 17136-17142. https://doi.org/10.1074/jbc.M909624199

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The nonconserved hydrophilic loop domain of presenilin (PS) is not required for PS endoproteolysis or enhanced Aβ42 production mediated by familial early onset Alzheimer's disease-linked PS variants

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