TY - JOUR
T1 - The effects of phosphate depletion on bone.
AU - Ivey, J. L.
AU - Morey, E. R.
AU - Baylink, D. J.
N1 - Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 103) The importance of phosphate in the metabolism of an organism has been indicated by many of the other papers in this volume.
PY - 1978
Y1 - 1978
N2 - Phosphate depletion causes significant changes in the composition of the cell population in bone and the metabolic activities of these cells. The data presented indicate that a vitamin D metabolite has a significant role in producing the increase in osteoclast number associated with phosphate depletion. The increased resorptive activity and number of osteoclasts leads to a marked increase in the rate of bone resorption resulting in the liberation of calcium phosphate, while the decrease in the rates of the processes involved in bone formation (matrix production, osteoid maturation, and mineralization) reduces the amount of phosphate which is removed from the circulation. Thus, all of the effects of phosphate depletion on bone are consistent with the interpretation that bone acts as a reservoir of phosphate and is used to maintain soft tissue and serum phosphate levels at the expense of bone.
AB - Phosphate depletion causes significant changes in the composition of the cell population in bone and the metabolic activities of these cells. The data presented indicate that a vitamin D metabolite has a significant role in producing the increase in osteoclast number associated with phosphate depletion. The increased resorptive activity and number of osteoclasts leads to a marked increase in the rate of bone resorption resulting in the liberation of calcium phosphate, while the decrease in the rates of the processes involved in bone formation (matrix production, osteoid maturation, and mineralization) reduces the amount of phosphate which is removed from the circulation. Thus, all of the effects of phosphate depletion on bone are consistent with the interpretation that bone acts as a reservoir of phosphate and is used to maintain soft tissue and serum phosphate levels at the expense of bone.
UR - https://www.scopus.com/pages/publications/0018169470
UR - https://www.scopus.com/pages/publications/0018169470#tab=citedBy
U2 - 10.1007/978-1-4684-7758-0_38
DO - 10.1007/978-1-4684-7758-0_38
M3 - Article
C2 - 717112
SN - 0065-2598
VL - 103
SP - 373
EP - 380
JO - Advances in Experimental Medicine and Biology
JF - Advances in Experimental Medicine and Biology
ER -