TY - JOUR
T1 - The effect of Portuguese Man-of-war (Physalia physalis) venom on calcium, sodium and potassium fluxes of cultured embryonic chick heart cells
AU - Edwards, Lincoln
AU - Luo, Eva
AU - Hall, Raymond
AU - Gonzalez, Ramon R.
AU - Hessinger, David A.
N1 - Portuguese Man-of-war venom markedly increases calcium (45Ca2+) influx into primary, cultured, embryonic chick heart cells. This action is dose-depend...
PY - 2000/3
Y1 - 2000/3
N2 - Portuguese Man-of-war venom markedly increases calcium (45Ca2+) influx into primary, cultured, embryonic chick heart cells. This action is dose-dependent, but is unaffected by organic calcium blockers (diltiazem, verapamil, nifedipine, nimodipine and mibefradil). On the other hand, certain trivalent (La3+, Gd(3+)) and divalent (Zn2+, Ni2+, Cu2+, Mn2+) metals inhibit venom-induced calcium influx. Sodium (22Na+) influx into chick heart cells is also significantly increased by Man-of-war venom. Flecainide does not block venom-induced sodium influx. The efflux of the potassium analogue, 86Rb+, from heart cells is also significantly increased by the venom. The venom, however, has little or no effect on rubidium (86Rb+) or 2-deoxy-D-[2-3H] glucose influx. Copyright (C) 1999 Elsevier Science Ltd.
AB - Portuguese Man-of-war venom markedly increases calcium (45Ca2+) influx into primary, cultured, embryonic chick heart cells. This action is dose-dependent, but is unaffected by organic calcium blockers (diltiazem, verapamil, nifedipine, nimodipine and mibefradil). On the other hand, certain trivalent (La3+, Gd(3+)) and divalent (Zn2+, Ni2+, Cu2+, Mn2+) metals inhibit venom-induced calcium influx. Sodium (22Na+) influx into chick heart cells is also significantly increased by Man-of-war venom. Flecainide does not block venom-induced sodium influx. The efflux of the potassium analogue, 86Rb+, from heart cells is also significantly increased by the venom. The venom, however, has little or no effect on rubidium (86Rb+) or 2-deoxy-D-[2-3H] glucose influx. Copyright (C) 1999 Elsevier Science Ltd.
KW - Calcium influx
KW - Cultured embryonic chick heart cells
KW - Hematocyst
KW - Physial Physalis
KW - Portugese Man-of-War
KW - Venom
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U2 - 10.1016/S0041-0101(99)00156-7
DO - 10.1016/S0041-0101(99)00156-7
M3 - Article
C2 - 10669022
SN - 0041-0101
VL - 38
SP - 323
EP - 335
JO - Toxicon
JF - Toxicon
IS - 3
ER -