TY - JOUR
T1 - The Effect of βAminopropionitrile (BAPN) on Bone Mineralization
AU - Rosenquist, Jan B.
AU - Baylink, David J.
AU - Spengler, Dan M.
N1 - Funding Information:
This work was supported in part by NIH grants DE-02600 and HD-04872. Dr. D. Baylink (MRIS 0483) is recipient of RCDA award DE-19108. Dr. Rosenquist received research and training support from the University of Umea and the Swedish Medical Research Council. 2
PY - 1977/2
Y1 - 1977/2
N2 - The process or bone mineralization in the tibial diaphysis, in response to treatment with a lathyrogen, βAminopropionitrile (BAPN), at a dose known to inhibit collagen crosslinking, was studied in growing rats. BAPN treatment impaired the initial rate of mineralization but not its onset. In addition, in the BAPN treated group, there was a 5% decrease in diaphyseal ash weight, a decrement estimated to be greater than expected from the decreased rate of mineralization. This suggests that the maximal level of mineral deposition was also decreased as a result of BAPN treatment.
AB - The process or bone mineralization in the tibial diaphysis, in response to treatment with a lathyrogen, βAminopropionitrile (BAPN), at a dose known to inhibit collagen crosslinking, was studied in growing rats. BAPN treatment impaired the initial rate of mineralization but not its onset. In addition, in the BAPN treated group, there was a 5% decrease in diaphyseal ash weight, a decrement estimated to be greater than expected from the decreased rate of mineralization. This suggests that the maximal level of mineral deposition was also decreased as a result of BAPN treatment.
UR - https://www.scopus.com/pages/publications/0017600167
UR - https://www.scopus.com/pages/publications/0017600167#tab=citedBy
U2 - 10.3181/00379727-154-39660
DO - 10.3181/00379727-154-39660
M3 - Article
C2 - 840869
SN - 0037-9727
VL - 154
SP - 310
EP - 313
JO - Proceedings of the Society for Experimental Biology and Medicine
JF - Proceedings of the Society for Experimental Biology and Medicine
IS - 2
ER -