The aspartate-257 of presenilin 1 is indispensable for mouse development and production of β-amyloid peptides through β-catenin-independent mechanisms

  • Xuefeng Xia
  • , Pei Wang
  • , Xiaoyan Sun
  • , Salvador Soriano
  • , Wan Kyng Shum
  • , Haruyasu Yamaguchi
  • , Myrna E. Trumbauer
  • , Akihiko Takashima
  • , Edward H. Koo
  • , Hui Zheng

Research output: Contribution to journalArticlepeer-review

Original languageEnglish
Pages (from-to)8760-8765
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume99
Issue number13
DOIs
StatePublished - Jun 25 2002
Externally publishedYes

ASJC Scopus Subject Areas

  • General

Keywords

  • Hydrolysis
  • Presenilin-1
  • Receptors, Notch
  • Animals
  • Aspartic Acid/metabolism
  • Membrane Proteins/chemistry
  • beta Catenin
  • Trans-Activators
  • Mice, Transgenic
  • Mice
  • Amyloid beta-Peptides/biosynthesis
  • Cytoskeletal Proteins/metabolism

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