Targeting DNA helicase CMG complex and NFκB2-driven drug-resistant transcriptional axis to effectively treat KRASG12D-mutated pancreatic cancer

Jeffrey Xiao; Joshua Kim; Brandon Park; David J. Baylink; Cedric Kwon; Victoria Tran; Scott Lee; Kevin Codorniz; Laren Tan; Pamela Lobo Moreno; Amy Schill-Depew; Saied Mirshahidi; David De Semir; Diana Hanna; Kiran Naqvi; Huynh Cao; Chien Shing Chen; Joanne Xiu; Heinz Josef Lenz; Hamid Mirshahidi; Mark E. Reeves; Yi Xu

doi:10.1186/s40164-025-00669-w

Targeting DNA helicase CMG complex and NFκB2-driven drug-resistant transcriptional axis to effectively treat KRAS^G12D-mutated pancreatic cancer

Jeffrey Xiao
, Joshua Kim
, Brandon Park
, David J. Baylink
, Cedric Kwon
, Victoria Tran
, Scott Lee
, Kevin Codorniz
, Laren Tan
, Pamela Lobo Moreno
, Amy Schill-Depew
, Saied Mirshahidi
, David De Semir
, Diana Hanna
, Kiran Naqvi
, Huynh Cao
, Chien Shing Chen
, Joanne Xiu
, Heinz Josef Lenz
, Hamid Mirshahidi

Research output: Contribution to journal › Letter › peer-review

Original language	English
Article number	79
Journal	Experimental Hematology and Oncology
Volume	14
Issue number	1
DOIs	https://doi.org/10.1186/s40164-025-00669-w
State	Published - May 26 2025

ASJC Scopus Subject Areas

Hematology
Oncology
Cancer Research

Keywords

ATP
Bedaquiline
DDIT
Helicase
KRAS
MRTX1133
Mitochondrion
NFκB2
PDAC
S100P

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10.1186/s40164-025-00669-w

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Cite this

Xiao, J., Kim, J., Park, B., Baylink, D. J., Kwon, C., Tran, V., Lee, S., Codorniz, K., Tan, L., Moreno, P. L., Schill-Depew, A., Mirshahidi, S., De Semir, D., Hanna, D., Naqvi, K., Cao, H., Chen, C. S., Xiu, J., Lenz, H. J., ... Xu, Y. (2025). Targeting DNA helicase CMG complex and NFκB2-driven drug-resistant transcriptional axis to effectively treat KRAS^G12D-mutated pancreatic cancer. Experimental Hematology and Oncology, 14(1), Article 79. https://doi.org/10.1186/s40164-025-00669-w

Xiao, J, Kim, J, Park, B, Baylink, DJ, Kwon, C, Tran, V , Lee, S , Codorniz, K , Tan, L , Moreno, PL , Schill-Depew, A , Mirshahidi, S, De Semir, D, Hanna, D, Naqvi, K, Cao, H, Chen, CS, Xiu, J, Lenz, HJ, Mirshahidi, H , Reeves, ME & Xu, Y 2025, 'Targeting DNA helicase CMG complex and NFκB2-driven drug-resistant transcriptional axis to effectively treat KRAS^G12D-mutated pancreatic cancer', Experimental Hematology and Oncology, vol. 14, no. 1, 79. https://doi.org/10.1186/s40164-025-00669-w

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AU - Kwon, Cedric

AU - Tran, Victoria

AU - Lee, Scott

AU - Codorniz, Kevin

AU - Tan, Laren

AU - Moreno, Pamela Lobo

AU - Schill-Depew, Amy

AU - Mirshahidi, Saied

AU - De Semir, David

AU - Hanna, Diana

AU - Naqvi, Kiran

AU - Cao, Huynh

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AU - Xiu, Joanne

AU - Lenz, Heinz Josef

AU - Mirshahidi, Hamid

AU - Reeves, Mark E.

AU - Xu, Yi

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KW - Helicase

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KW - Mitochondrion

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KW - S100P

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