TY - JOUR
T1 - Synthesis and evaluation of duocarmycin SA analogs incorporating the methyl 1,2,8,8a-tetrahydrocyclopropa[c]oxazolo[2,3-e]indol-4-one-6-carboxylate (COI) alkylation subunit
AU - Boyle, Kristopher E.
AU - MacMillan, Karen S.
AU - Ellis, David A.
AU - Lajiness, James P.
AU - Robertson, William M.
AU - Boger, Dale L.
N1 - Funding Information:
We gratefully acknowledge the financial support of the National Institutes of Health ( CA041986 ) and the Skaggs Institute for Chemical Biology. K.S.M., J.P.L., and W.M.R. were Skaggs Fellows.
PY - 2010/3/15
Y1 - 2010/3/15
N2 - The design, synthesis and evaluation of methyl 1,2,8,8a-tetrahydrocyclopropa[c]oxazolo[2,3-e]indol-4-one-6-carboxylate (COI) derivatives are detailed representing analogs of duocarmycin SA containing an oxazole replacement for the fused pyrrole found in the alkylation subunit.
AB - The design, synthesis and evaluation of methyl 1,2,8,8a-tetrahydrocyclopropa[c]oxazolo[2,3-e]indol-4-one-6-carboxylate (COI) derivatives are detailed representing analogs of duocarmycin SA containing an oxazole replacement for the fused pyrrole found in the alkylation subunit.
KW - Antitumor drugs
KW - DNA alkylating agents
KW - Duocarmycins
UR - https://www.scopus.com/pages/publications/77549086561
UR - https://www.scopus.com/pages/publications/77549086561#tab=citedBy
U2 - 10.1016/j.bmcl.2010.01.145
DO - 10.1016/j.bmcl.2010.01.145
M3 - Article
C2 - 20171886
SN - 0960-894X
VL - 20
SP - 1854
EP - 1857
JO - Bioorganic and Medicinal Chemistry Letters
JF - Bioorganic and Medicinal Chemistry Letters
IS - 6
ER -