TY - JOUR
T1 - Subretinal Fibrosis in Central Serous Chorioretinopathy
AU - Schatz, Howard
AU - McDonald, H. Richard
AU - Johnson, Robert N.
AU - Chan, Clement K.
AU - Irvine, Alexander R.
AU - Berger, Alan R.
AU - Folk, James C.
AU - Robertson, Dennis M.
N1 - Funding Information:
Originally received: October 24, 1994. Revision accepted: February 28, 1995. I Retina Research Fund of St. Mary's Medical Center, San Francisco. 2 Department of Ophthalmology, Lorna Linda University, Lorna Linda, California. 3 Department of Ophthalmology, University of California Medical Center, San Francisco. 4 Department of Ophthalmology, Sunnybrook Health Science Center, University of Toronto, Toronto. 5 Department of Ophthalmology, University ofIowa, College of Medicine, Iowa City. 6 Department of Ophthalmology, Mayo Clinic, Rochester. Supported by the Retina Research Fund of St. Mary's Hospital and Medical Center, San Francisco, California, and by a grant from the Wayne and Gladys Valley Foundation, San Ramon, California. Reprint requests to Howard Schatz, MD, I Daniel Burnham Ct, San Francisco, CA 94109.
PY - 1995
Y1 - 1995
N2 - Purpose: To report unusual and heretofore unreported visually damaging manifestations of severe central serous chorioretinopathy. Methods: Case studies. Results: Each of six male patients (average age, 40 years) had a form of severe central serous chorioretinopathy with at least one eye containing fibrin in the subretinal space that then developed into a subretinal fibrotic scar. Scar formation was followed by a tenting up of the macula, vascularization of the fibrosis (subretinal neovascularization), or a retinal pigment epithelial rip. Four of the seven eyes with subretinal fibrosis had severe visual loss (20/400 or worse). Conclusion: Subretinal fibrin and other extracellular matrix molecules appear to stimulate the retinal pigment epithelium to undergo fibrous metaplasia, which results in subretinal fibrotic scar formation and other sequelae, all of which can lead to severe visual loss.
AB - Purpose: To report unusual and heretofore unreported visually damaging manifestations of severe central serous chorioretinopathy. Methods: Case studies. Results: Each of six male patients (average age, 40 years) had a form of severe central serous chorioretinopathy with at least one eye containing fibrin in the subretinal space that then developed into a subretinal fibrotic scar. Scar formation was followed by a tenting up of the macula, vascularization of the fibrosis (subretinal neovascularization), or a retinal pigment epithelial rip. Four of the seven eyes with subretinal fibrosis had severe visual loss (20/400 or worse). Conclusion: Subretinal fibrin and other extracellular matrix molecules appear to stimulate the retinal pigment epithelium to undergo fibrous metaplasia, which results in subretinal fibrotic scar formation and other sequelae, all of which can lead to severe visual loss.
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U2 - 10.1016/S0161-6420(95)30908-6
DO - 10.1016/S0161-6420(95)30908-6
M3 - Article
C2 - 9121756
SN - 0161-6420
VL - 102
SP - 1077
EP - 1088
JO - Ophthalmology
JF - Ophthalmology
IS - 7
ER -