STZ-induced gestational diabetes exposure alters PTEN/AKT/mTOR-mediated autophagy signaling pathway leading to increase the risk of neonatal hypoxic-ischemic encephalopathy

Lei Gong, Siyi Jiang, Jia Tian, Yong Li, Wansu Yu, Lubo Zhang, Daliao Xiao

Research output: Contribution to journalArticlepeer-review

Original languageEnglish
Article number108494
JournalReproductive Toxicology
Volume123
DOIs
StatePublished - Jan 2024

ASJC Scopus Subject Areas

  • Toxicology

Keywords

  • Autophagy
  • GDM
  • Neonatal brain ischemia-sensitive phenotype
  • PTEN/AKT/mTOR
  • Animals, Newborn
  • Diabetes, Gestational/chemically induced
  • Prenatal Exposure Delayed Effects
  • Streptozocin
  • Autophagy/drug effects
  • Rats
  • Male
  • Blood Glucose
  • Proto-Oncogene Proteins c-akt/metabolism
  • Rats, Sprague-Dawley
  • Signal Transduction/drug effects
  • Pregnancy
  • PTEN Phosphohydrolase/metabolism
  • Animals
  • Hypoxia-Ischemia, Brain/metabolism
  • Female
  • TOR Serine-Threonine Kinases/metabolism
  • Brain/metabolism

Cite this