Studying SARS-CoV-2 infectivity and therapeutic responses with complex organoids

Kevin G. Chen; Kyeyoon Park; Jason R. Spence

doi:10.1038/s41556-021-00721-x

Studying SARS-CoV-2 infectivity and therapeutic responses with complex organoids

Kevin G. Chen
, Kyeyoon Park
, Jason R. Spence

Research output: Contribution to journal › Review article › peer-review

Abstract

Clinical management of patients with severe complications of COVID-19 has been hindered by a lack of effective drugs and a failure to capture the extensive heterogeneity of the disease with conventional methods. Here we review the emerging roles of complex organoids in the study of SARS-CoV-2 infection, modelling of COVID-19 disease pathology and in drug, antibody and vaccine development. We discuss opportunities for COVID-19 research and remaining challenges in the application of organoids.

Original language	English
Pages (from-to)	822-833
Number of pages	12
Journal	Nature Cell Biology
Volume	23
Issue number	8
DOIs	https://doi.org/10.1038/s41556-021-00721-x
State	Published - Aug 2021
Externally published	Yes

ASJC Scopus Subject Areas

Cell Biology

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10.1038/s41556-021-00721-x

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Studying SARS-CoV-2 infectivity and therapeutic responses with complex organoids

Abstract

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