Structure and characterization of the human insulin-like growth factor binding protein (IGFBP)-6 promoter: Identification of a functional retinoid response element

Yves P. Dailly; Yuehua Zhou; Thomas A. Linkhart; David J. Baylink; Donna D. Strong

doi:10.1016/S0167-4781(01)00192-0

Structure and characterization of the human insulin-like growth factor binding protein (IGFBP)-6 promoter: Identification of a functional retinoid response element

Yves P. Dailly, Yuehua Zhou, Thomas A. Linkhart, David J. Baylink, Donna D. Strong

Research output: Contribution to journal › Article › peer-review

Abstract

The 1.7 kb human insulin-like growth factor binding protein (IGFBP)-6 gene 5′-flanking region was sequenced and found to have promoter activity in human osteoblasts. The sequence contains four clustered transcription start sites and three retinoic acid response elements (RAREs) with widely spaced half-sites. Only the proximal DR15 RARE was functional. Retinoids increased IGFBP-6 promoter activity up to 3-fold.

Original language	English
Pages (from-to)	145-151
Number of pages	7
Journal	Biochimica et Biophysica Acta - Gene Structure and Expression
Volume	1518
Issue number	1-2
DOIs	https://doi.org/10.1016/S0167-4781(01)00192-0
State	Published - Mar 19 2001

ASJC Scopus Subject Areas

Structural Biology
Biophysics
Biochemistry
Genetics

Keywords

Osteoblast
Promoter
Retinoic acid
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Dailly, Y. P., Zhou, Y., Linkhart, T. A., Baylink, D. J., & Strong, D. D. (2001). Structure and characterization of the human insulin-like growth factor binding protein (IGFBP)-6 promoter: Identification of a functional retinoid response element. Biochimica et Biophysica Acta - Gene Structure and Expression, 1518(1-2), 145-151. https://doi.org/10.1016/S0167-4781(01)00192-0

Structure and characterization of the human insulin-like growth factor binding protein (IGFBP)-6 promoter: Identification of a functional retinoid response element. / Dailly, Yves P.; Zhou, Yuehua; Linkhart, Thomas A. et al.
In: Biochimica et Biophysica Acta - Gene Structure and Expression, Vol. 1518, No. 1-2, 19.03.2001, p. 145-151.

Research output: Contribution to journal › Article › peer-review

Dailly, YP, Zhou, Y, Linkhart, TA, Baylink, DJ & Strong, DD 2001, 'Structure and characterization of the human insulin-like growth factor binding protein (IGFBP)-6 promoter: Identification of a functional retinoid response element', Biochimica et Biophysica Acta - Gene Structure and Expression, vol. 1518, no. 1-2, pp. 145-151. https://doi.org/10.1016/S0167-4781(01)00192-0

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abstract = "The 1.7 kb human insulin-like growth factor binding protein (IGFBP)-6 gene 5′-flanking region was sequenced and found to have promoter activity in human osteoblasts. The sequence contains four clustered transcription start sites and three retinoic acid response elements (RAREs) with widely spaced half-sites. Only the proximal DR15 RARE was functional. Retinoids increased IGFBP-6 promoter activity up to 3-fold.",

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Structure and characterization of the human insulin-like growth factor binding protein (IGFBP)-6 promoter: Identification of a functional retinoid response element

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Keywords

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