Abstract
Mitochondrial dysfunction is an important pathological process in the setting of ischemic brain injury. Stem cell-mediated mitochondrial transfer provides an efficient intercellular process to supply additional mitochondria in the ischemic brain tissues. In this review, we summarize the mitochondrial pathology associated with brain ischemia, mechanisms of stem cell-mediated mitochondrial transfer, and in vitro/in vivo experimental findings of mitochondrial transfer from stem cells to ischemic vascular endothelial cells/neurons as potential therapeutic strategy in the management of ischemic brain injury.
| Original language | English |
|---|---|
| Pages (from-to) | 555-561 |
| Number of pages | 7 |
| Journal | Stem Cells and Development |
| Volume | 29 |
| Issue number | 9 |
| DOIs | |
| State | Published - May 1 2020 |
ASJC Scopus Subject Areas
- Hematology
- Developmental Biology
- Cell Biology
Keywords
- Cx43
- MSCs
- Miro1
- TNTs
- brain ischemia
- mitochondrial dysfunction
- mitochondrial transfer
- Cell- and Tissue-Based Therapy/methods
- Humans
- Neurons/cytology
- Endothelial Cells/cytology
- Animals
- Brain Ischemia/therapy
- Stem Cells/cytology
- Mitochondria/physiology
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