TY - JOUR
T1 - Stem Cell Therapy in Brain Ischemia
T2 - The Role of Mitochondrial Transfer
AU - Huang, Lei
AU - Reis, Cesar
AU - Boling, Warren W.
AU - Zhang, John H.
N1 - Publisher Copyright:
© Copyright 2020, Mary Ann Liebert, Inc., publishers 2020.
PY - 2020/5/1
Y1 - 2020/5/1
N2 - Mitochondrial dysfunction is an important pathological process in the setting of ischemic brain injury. Stem cell-mediated mitochondrial transfer provides an efficient intercellular process to supply additional mitochondria in the ischemic brain tissues. In this review, we summarize the mitochondrial pathology associated with brain ischemia, mechanisms of stem cell-mediated mitochondrial transfer, and in vitro/in vivo experimental findings of mitochondrial transfer from stem cells to ischemic vascular endothelial cells/neurons as potential therapeutic strategy in the management of ischemic brain injury.
AB - Mitochondrial dysfunction is an important pathological process in the setting of ischemic brain injury. Stem cell-mediated mitochondrial transfer provides an efficient intercellular process to supply additional mitochondria in the ischemic brain tissues. In this review, we summarize the mitochondrial pathology associated with brain ischemia, mechanisms of stem cell-mediated mitochondrial transfer, and in vitro/in vivo experimental findings of mitochondrial transfer from stem cells to ischemic vascular endothelial cells/neurons as potential therapeutic strategy in the management of ischemic brain injury.
KW - Cx43
KW - MSCs
KW - Miro1
KW - TNTs
KW - brain ischemia
KW - mitochondrial dysfunction
KW - mitochondrial transfer
KW - Cell- and Tissue-Based Therapy/methods
KW - Humans
KW - Neurons/cytology
KW - Endothelial Cells/cytology
KW - Animals
KW - Brain Ischemia/therapy
KW - Stem Cells/cytology
KW - Mitochondria/physiology
UR - http://www.scopus.com/inward/record.url?scp=85084293048&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85084293048&partnerID=8YFLogxK
UR - https://www.mendeley.com/catalogue/628aad47-9da1-3d4b-8656-158024119ad5/
U2 - 10.1089/scd.2019.0237
DO - 10.1089/scd.2019.0237
M3 - Article
C2 - 31964239
SN - 1547-3287
VL - 29
SP - 555
EP - 561
JO - Stem Cells and Development
JF - Stem Cells and Development
IS - 9
ER -