Sperm DNA Fragmentation: A Critical Assessment of Clinical Practice Guidelines

Ashok Agarwal; Alaa Farkouh; Neel Parekh; Armand Zini; Mohamed Arafa; Hussein Kandil; Nick Tadros; Gian Maria Busetto; Rafael Ambar; Sijo Parekattil; Florence Boitrelle; Hassan Sallam; Sunil Jindal; Edmund Ko; Mara Simopoulou; Hyun Jun Park; Mohammad Ali Sadighi; Ramadan Saleh; Jonathan Ramsay; Marlon Martinez; Haitham Elbardisi; Juan Alvarez; Giovanni Colpi; Jaime Gosalvez; Donald Evenson; Rupin Shah

doi:10.5534/wjmh.210056

Sperm DNA Fragmentation: A Critical Assessment of Clinical Practice Guidelines

Ashok Agarwal
, Alaa Farkouh
, Neel Parekh
, Armand Zini
, Mohamed Arafa
, Hussein Kandil
, Nick Tadros
, Gian Maria Busetto
, Rafael Ambar
, Sijo Parekattil
, Florence Boitrelle
, Hassan Sallam
, Sunil Jindal
, Edmund Ko
, Mara Simopoulou
, Hyun Jun Park
, Mohammad Ali Sadighi
, Ramadan Saleh
, Jonathan Ramsay
, Marlon Martinez

Haitham Elbardisi, Juan Alvarez, Giovanni Colpi, Jaime Gosalvez, Donald Evenson, Rupin Shah

Urology

Research output: Contribution to journal › Review article › peer-review

Abstract

Sperm DNA fragmentation (SDF) is implicated in male infertility and adverse reproductive outcomes. With the publication of many studies regarding the etiologies and contributors to SDF, as well as the effects of SDF, guidelines are necessary to aid clinicians in the application of SDF for male fertility evaluation. Two recent clinical practice guidelines were published by Agarwal et al and Esteves et al. In this article, we have evaluated and compared both guidelines. We have found fairly similar recommendations between the two guidelines and have also highlighted the differences between them. Finally, we have summarized and combined the best practice recommendations from both guidelines.

Original language	English
Pages (from-to)	30-37
Number of pages	8
Journal	World Journal of Men's Health
Volume	40
Issue number	1
DOIs	https://doi.org/10.5534/wjmh.210056
State	Published - Jan 1 2022

ASJC Scopus Subject Areas

Reproductive Medicine
Aging
Health Policy
Public Health, Environmental and Occupational Health
Psychiatry and Mental health
Urology
Pharmacology (medical)

Keywords

DNA fragmentation
Male infertility
Oxidative stress
Practice guidelines as topic
Reproductive techniques, assisted

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10.5534/wjmh.210056

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Agarwal, A., Farkouh, A., Parekh, N., Zini, A., Arafa, M., Kandil, H., Tadros, N., Busetto, G. M., Ambar, R., Parekattil, S., Boitrelle, F., Sallam, H., Jindal, S., Ko, E., Simopoulou, M., Park, H. J., Sadighi, M. A., Saleh, R., Ramsay, J., ... Shah, R. (2022). Sperm DNA Fragmentation: A Critical Assessment of Clinical Practice Guidelines. World Journal of Men's Health, 40(1), 30-37. https://doi.org/10.5534/wjmh.210056

Agarwal, A, Farkouh, A, Parekh, N, Zini, A, Arafa, M, Kandil, H, Tadros, N, Busetto, GM, Ambar, R, Parekattil, S, Boitrelle, F, Sallam, H, Jindal, S, Ko, E, Simopoulou, M, Park, HJ, Sadighi, MA, Saleh, R, Ramsay, J, Martinez, M, Elbardisi, H, Alvarez, J, Colpi, G, Gosalvez, J, Evenson, D & Shah, R 2022, 'Sperm DNA Fragmentation: A Critical Assessment of Clinical Practice Guidelines', World Journal of Men's Health, vol. 40, no. 1, pp. 30-37. https://doi.org/10.5534/wjmh.210056

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abstract = "Sperm DNA fragmentation (SDF) is implicated in male infertility and adverse reproductive outcomes. With the publication of many studies regarding the etiologies and contributors to SDF, as well as the effects of SDF, guidelines are necessary to aid clinicians in the application of SDF for male fertility evaluation. Two recent clinical practice guidelines were published by Agarwal et al and Esteves et al. In this article, we have evaluated and compared both guidelines. We have found fairly similar recommendations between the two guidelines and have also highlighted the differences between them. Finally, we have summarized and combined the best practice recommendations from both guidelines.",

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AU - Alvarez, Juan

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ER -

Sperm DNA Fragmentation: A Critical Assessment of Clinical Practice Guidelines

Abstract

ASJC Scopus Subject Areas

Keywords

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