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SMAC mimetic birinapant plus radiation eradicates human head and neck cancers with genomic amplifications of cell death genes FADD and BIRC2

  • Danielle F. Eytan
  • , Grace E. Snow
  • , Sophie Carlson
  • , Adeeb Derakhshan
  • , Anthony Saleh
  • , Stephen Schiltz
  • , Hui Cheng
  • , Suresh Mohan
  • , Shaleeka Cornelius
  • , Jamie Coupar
  • , Anastasia L. Sowers
  • , Lidia Hernandez
  • , James B. Mitchell
  • , Christina M. Annunziata
  • , Zhong Chen
  • , Carter Van Waes

Research output: Contribution to journal › Article › peer-review

Original languageEnglish
Pages (from-to)5442-5454
Number of pages13
JournalCancer Research
Volume76
Issue number18
DOIs
StatePublished - Sep 15 2016
Externally publishedYes

ASJC Scopus Subject Areas

  • Oncology
  • Cancer Research

Keywords

  • Immunohistochemistry
  • Antineoplastic Agents/administration & dosage
  • Humans
  • Tumor Necrosis Factor-alpha/administration & dosage
  • Gene Knockdown Techniques
  • Indoles/administration & dosage
  • Squamous Cell Carcinoma of Head and Neck
  • Carcinoma, Squamous Cell/genetics
  • Fas-Associated Death Domain Protein/genetics
  • Female
  • Real-Time Polymerase Chain Reaction
  • Head and Neck Neoplasms/genetics
  • Mice, SCID
  • Blotting, Western
  • Dipeptides/administration & dosage
  • Chemoradiotherapy/methods
  • TNF-Related Apoptosis-Inducing Ligand/administration & dosage
  • Xenograft Model Antitumor Assays
  • Animals
  • Gene Amplification
  • Cell Line, Tumor
  • Inhibitor of Apoptosis Proteins/genetics
  • Mice
  • Mice, Inbred BALB C
  • Ubiquitin-Protein Ligases/genetics

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