SIRT1 is required for mitochondrial biogenesis reprogrammingin hypoxic human pulmonary arteriolar smooth muscle cells

  • Pengyun Li
  • , Yan Liu
  • , Nana Burns
  • , Ke Seng Zhao
  • , Rui Song

Research output: Contribution to journalArticlepeer-review

Original languageEnglish
Pages (from-to)1127-1136
Number of pages10
JournalInternational Journal of Molecular Medicine
Volume39
Issue number5
DOIs
StatePublished - May 2017
Externally publishedYes

ASJC Scopus Subject Areas

  • Genetics

Keywords

  • Hypoxia
  • Mitochondria
  • Polydatin
  • Pulmonary arteriolar smooth muscle cells
  • Sirtuin
  • Gene Expression
  • Humans
  • Pulmonary Artery/cytology
  • Glucosides/pharmacology
  • Transcription Factors/genetics
  • Myocytes, Smooth Muscle/drug effects
  • Mitochondria, Muscle/drug effects
  • Gene Knockdown Techniques
  • Organelle Biogenesis
  • Sirtuin 1/genetics
  • Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha/metabolism
  • DNA-Binding Proteins/genetics
  • Models, Biological
  • Sirtuin 3/metabolism
  • Biomarkers
  • Mitochondrial Proteins/genetics
  • Stilbenes/pharmacology
  • Hypoxia/genetics

Cite this