Signaling Pathways in Bacterial Chemotaxis

B. L. Taylor; M. S. Johnson; J. M. Smith

doi:10.1111/j.1438-8677.1988.tb00018.x

Signaling Pathways in Bacterial Chemotaxis

B. L. Taylor, M. S. Johnson, J. M. Smith

Microbiology Division

Research output: Contribution to journal › Article › peer-review

Abstract

The sensory transduction pathways between the transducing proteins and the switch on the flagellar motors have been investigated in Escherichia coli and Salmonella typhimurium. ATP, not GTP, is required for normal chemotaxis. A site of ATP action appears to be the conversion of an inactive form of the CheY protein to an active form, designated CheY*, that binds to the motor switch and initiates clockwise rotation. The methylation‐dependent and methylation‐independent pathways for chemotaxis have a common requirement for the CheA, CheW, and CheY proteins in addition to the switch and flagellar motor. It is concluded that the receptor/transducing proteins and the adaptation mechanism differ in the two types of pathway, but that other components of the transduction pathway are common to the methylation‐dependent and methylation‐independent pathways. 1988 Deutsche Botanische Gesellschaft/German Botanical Society

Original language	English
Pages (from-to)	101-104
Number of pages	4
Journal	Botanica Acta
Volume	101
Issue number	2
DOIs	https://doi.org/10.1111/j.1438-8677.1988.tb00018.x
State	Published - May 1988

ASJC Scopus Subject Areas

Plant Science

Keywords

ATP
Chemotaxis
cheY product
methylation‐independent
sensory transduction

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N2 - The sensory transduction pathways between the transducing proteins and the switch on the flagellar motors have been investigated in Escherichia coli and Salmonella typhimurium. ATP, not GTP, is required for normal chemotaxis. A site of ATP action appears to be the conversion of an inactive form of the CheY protein to an active form, designated CheY*, that binds to the motor switch and initiates clockwise rotation. The methylation‐dependent and methylation‐independent pathways for chemotaxis have a common requirement for the CheA, CheW, and CheY proteins in addition to the switch and flagellar motor. It is concluded that the receptor/transducing proteins and the adaptation mechanism differ in the two types of pathway, but that other components of the transduction pathway are common to the methylation‐dependent and methylation‐independent pathways. 1988 Deutsche Botanische Gesellschaft/German Botanical Society

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Signaling Pathways in Bacterial Chemotaxis

Abstract

ASJC Scopus Subject Areas

Keywords

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