TY - JOUR
T1 - Serum organochlorines and breast cancer
T2 - A case-control study among African-American women
AU - Gatto, Nicole M.
AU - Longnecker, Matthew P.
AU - Press, Michael F.
AU - Sullivan-Halley, Jane
AU - McKean-Cowdin, Roberta
AU - Bernstein, Leslie
N1 - Funding Information:
Acknowledgments This study was supported by the National Institute of Child Health and Human Development, with additional support from the National Cancer Institute (NCI), through a contract with the University of Southern California University of Southern California (N01 HD 3–3175), by a grant from the National Institute of Environmental Health Sciences (NIEHS), ES07084, and in part by the Intramural Research Program of the National Institutes of Health, NIEHS. General support from NCI through the SEER Program contract to the Cancer Surveillance Program for Los Angeles County (N01-CN-67010) is also acknowledged. The collection of cancer incidence data for Los Angeles County used in this publication was also supported by the California Department of Health Services as part of the statewide cancer reporting program mandated by the California Health and Safety Code Section 103885. The ideas and opinions expressed herein are those of the authors, and no endorsement by the State of California, Department of Health Services, is intended or should be inferred.
PY - 2007/2
Y1 - 2007/2
N2 - This population-based case-control study of African-American women (355 breast cancer case patients, 327 controls) examined the association between breast cancer and circulating levels of PCBs and dichlorodiphenyldichloroethene (DDE), a metabolite of DDT. Case patients were diagnosed with invasive breast carcinoma and interviewed between June 1995 and July 1998, and control subjects were identified by random digit dialing methods. Serum levels of DDE and total PCBs were adjusted for total lipid content. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using multivariable unconditional logistic regression methods. Effect modification by tumor receptor status and cancer treatment was investigated. Breast cancer risk was not associated with increasing quintiles of lipid-adjusted PCBs or DDE (highest versus lowest quintile adjusted for age, body mass index (BMI) and breastfeeding for DDE: OR = 1.02, 95% CI = (0.61, 1.72), p-trend = 0.74; for PCBs: OR = 1.01, 95% CI = (0.63, 1.63), p-trend = 0.56). Risk did not differ by strata of BMI, breastfeeding, parity, menopausal status or tumor receptor status. This study, the largest study of African-American women to date, does not support a role of DDE and total PCBs in breast cancer risk at the levels measured.
AB - This population-based case-control study of African-American women (355 breast cancer case patients, 327 controls) examined the association between breast cancer and circulating levels of PCBs and dichlorodiphenyldichloroethene (DDE), a metabolite of DDT. Case patients were diagnosed with invasive breast carcinoma and interviewed between June 1995 and July 1998, and control subjects were identified by random digit dialing methods. Serum levels of DDE and total PCBs were adjusted for total lipid content. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using multivariable unconditional logistic regression methods. Effect modification by tumor receptor status and cancer treatment was investigated. Breast cancer risk was not associated with increasing quintiles of lipid-adjusted PCBs or DDE (highest versus lowest quintile adjusted for age, body mass index (BMI) and breastfeeding for DDE: OR = 1.02, 95% CI = (0.61, 1.72), p-trend = 0.74; for PCBs: OR = 1.01, 95% CI = (0.63, 1.63), p-trend = 0.56). Risk did not differ by strata of BMI, breastfeeding, parity, menopausal status or tumor receptor status. This study, the largest study of African-American women to date, does not support a role of DDE and total PCBs in breast cancer risk at the levels measured.
KW - African-Americans
KW - Breast cancer
KW - Cancer
KW - DDE
KW - DDT
KW - Organochlorines
KW - PCBs
KW - Pesticides
KW - Women
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U2 - 10.1007/s10552-006-0070-2
DO - 10.1007/s10552-006-0070-2
M3 - Article
C2 - 17186420
SN - 0957-5243
VL - 18
SP - 29
EP - 39
JO - Cancer Causes and Control
JF - Cancer Causes and Control
IS - 1
ER -