TY - JOUR
T1 - Serotonergic Response to Spinal Distraction Trauma in Experimental Scoliosis
AU - Salzman, Steven K.
AU - Mendez, Armando A.
AU - Dabney, Kirk W.
AU - Daley, Joseph C.
AU - Freeman, Gina M.
AU - el-Tantawi, S.
AU - Beckman, Alexander L.
AU - Bunnell, William P.
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PY - 1991
Y1 - 1991
N2 - The effects of distraction injury to the spinal cord on serotonin (5HT) content and metabolism in a rat model of scoliosis were studied. Previous studies in this laboratory (Salzman et al., 1987a) have identified the 5HT response as a major component of the posttraumatic progression of spinal injury after impact trauma in the rabbit. The present study was designed to determine the universality of this response by examining a different model of injury in a different species. The results demonstrate that distraction trauma in the rat, like impact injury in the rabbit, is associated with a rapid and robust increase in the local spinal cord content and metabolism of 5HT and a long-term depletion of 5HT below the site of injury. The roles of the blood platelet and the raphe-spinal tract in the acute response and the disruption of axoplasmic transport during the chronic phase of injury are discussed.
AB - The effects of distraction injury to the spinal cord on serotonin (5HT) content and metabolism in a rat model of scoliosis were studied. Previous studies in this laboratory (Salzman et al., 1987a) have identified the 5HT response as a major component of the posttraumatic progression of spinal injury after impact trauma in the rabbit. The present study was designed to determine the universality of this response by examining a different model of injury in a different species. The results demonstrate that distraction trauma in the rat, like impact injury in the rabbit, is associated with a rapid and robust increase in the local spinal cord content and metabolism of 5HT and a long-term depletion of 5HT below the site of injury. The roles of the blood platelet and the raphe-spinal tract in the acute response and the disruption of axoplasmic transport during the chronic phase of injury are discussed.
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U2 - 10.1089/neu.1991.8.45
DO - 10.1089/neu.1991.8.45
M3 - Article
C2 - 1712851
SN - 0897-7151
VL - 8
SP - 45
EP - 54
JO - Journal of Neurotrauma
JF - Journal of Neurotrauma
IS - 1
ER -