TY - JOUR
T1 - Sepsis in the 21st century
T2 - recent definitions and therapeutic advances
AU - Nguyen, H. Bryant
AU - Smith, Dustin
N1 - Sepsis as a disease has received renewed interests since recent publications of a revised clinical definition and crucial clinical trials showing the ...
PY - 2007/6
Y1 - 2007/6
N2 - Sepsis as a disease has received renewed interests since recent publications of a revised clinical definition and crucial clinical trials showing the benefits of early goal-directed resuscitation, recombinant human activated protein C, and low-dose corticosteroids. The epidemiology of sepsis has also been further examined. Management guidelines and international quality improvement efforts have been developed targeting increased disease identification, clinician education, and optimal patient care with the result of decreasing patient mortality. The evidence suggests that early recognition and early intervention are most important in affecting outcome. This article will summarize these developments in the diagnosis and management of sepsis at the turn of this century.
AB - Sepsis as a disease has received renewed interests since recent publications of a revised clinical definition and crucial clinical trials showing the benefits of early goal-directed resuscitation, recombinant human activated protein C, and low-dose corticosteroids. The epidemiology of sepsis has also been further examined. Management guidelines and international quality improvement efforts have been developed targeting increased disease identification, clinician education, and optimal patient care with the result of decreasing patient mortality. The evidence suggests that early recognition and early intervention are most important in affecting outcome. This article will summarize these developments in the diagnosis and management of sepsis at the turn of this century.
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U2 - 10.1016/j.ajem.2006.08.015
DO - 10.1016/j.ajem.2006.08.015
M3 - Review article
C2 - 17543662
SN - 0735-6757
VL - 25
SP - 564
EP - 571
JO - American Journal of Emergency Medicine
JF - American Journal of Emergency Medicine
IS - 5
ER -