Seizure-induced basal dendrites on granule cells

Charles E. Ribak; Lee A. Shapiro; Xiao Xin Yan; Khashayar Dashtipour; J. Victor Nadler; Andre Obenaus; Igor Spigelman; Paul S. Buckmaster

doi:10.1111/j.1528-1167.2010.02829.x

Seizure-induced basal dendrites on granule cells

Charles E. Ribak, Lee A. Shapiro, Xiao Xin Yan, Khashayar Dashtipour, J. Victor Nadler, Andre Obenaus, Igor Spigelman, Paul S. Buckmaster

Research output: Contribution to journal › Article › peer-review

Abstract

Seizure-induced hilar basal dendrites on dentate granule cells are observed in several rodent models of temporal lobe epilepsy. Ultrastructural evidence showed that basal dendrites receive predominantly excitatory synapses, including many from mossy fibers. Such highly interconnected granule cells with basal dendrites are suggested to enhance hyperexcitability within the dentate network. For an expanded treatment of this topic see Jasper's Basic Mechanisms of the Epilepsies, Fourth Edition (Noebels JL, Avoli M, Rogawski MA, Olsen RW, Delgado-Escueta AV, eds) published by Oxford University Press (available on the National Library of Medicine Bookshelf [NCBI] at).

Original language	English
Pages (from-to)	43
Number of pages	1
Journal	Epilepsia
Volume	51
Issue number	SUPPL. 5
DOIs	https://doi.org/10.1111/j.1528-1167.2010.02829.x
State	Published - Dec 2010

ASJC Scopus Subject Areas

Neurology
Clinical Neurology

Keywords

Astrocytes
Doublecortin
Electron microscopy
Epilepsy
Excitation
Neurogenesis
Neuroplasticity

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title = "Seizure-induced basal dendrites on granule cells",

abstract = "Seizure-induced hilar basal dendrites on dentate granule cells are observed in several rodent models of temporal lobe epilepsy. Ultrastructural evidence showed that basal dendrites receive predominantly excitatory synapses, including many from mossy fibers. Such highly interconnected granule cells with basal dendrites are suggested to enhance hyperexcitability within the dentate network. For an expanded treatment of this topic see Jasper's Basic Mechanisms of the Epilepsies, Fourth Edition (Noebels JL, Avoli M, Rogawski MA, Olsen RW, Delgado-Escueta AV, eds) published by Oxford University Press (available on the National Library of Medicine Bookshelf [NCBI] at).",

keywords = "Astrocytes, Doublecortin, Electron microscopy, Epilepsy, Excitation, Neurogenesis, Neuroplasticity",

author = "Ribak, {Charles E.} and Shapiro, {Lee A.} and Yan, {Xiao Xin} and Khashayar Dashtipour and Nadler, {J. Victor} and Andre Obenaus and Igor Spigelman and Buckmaster, {Paul S.}",

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AU - Shapiro, Lee A.

AU - Yan, Xiao Xin

AU - Dashtipour, Khashayar

AU - Nadler, J. Victor

AU - Obenaus, Andre

AU - Spigelman, Igor

AU - Buckmaster, Paul S.

N1 - Author(s): Ribak, CE; Shapiro, LA; Yan, XX; Dashtipour, K; Nadler, JV; Obenaus, A; Spigelman, I; Buckmaster, PS | Abstract: Seizure-induced hilar basal dendrites on dentate granule cells are observed in several rodent models of temporal lobe epilepsy. Ultrastructural evidence showed that basal dendrites receive predominantly excitatory synapses, including many from mossy fibers.

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AB - Seizure-induced hilar basal dendrites on dentate granule cells are observed in several rodent models of temporal lobe epilepsy. Ultrastructural evidence showed that basal dendrites receive predominantly excitatory synapses, including many from mossy fibers. Such highly interconnected granule cells with basal dendrites are suggested to enhance hyperexcitability within the dentate network. For an expanded treatment of this topic see Jasper's Basic Mechanisms of the Epilepsies, Fourth Edition (Noebels JL, Avoli M, Rogawski MA, Olsen RW, Delgado-Escueta AV, eds) published by Oxford University Press (available on the National Library of Medicine Bookshelf [NCBI] at).

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KW - Doublecortin

KW - Electron microscopy

KW - Epilepsy

KW - Excitation

KW - Neurogenesis

KW - Neuroplasticity

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Seizure-induced basal dendrites on granule cells

Abstract

ASJC Scopus Subject Areas

Keywords

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