SCD1 inhibition causes cancer cell death by depleting mono-unsaturated fatty acids

Paul Mason; Beirong Liang; Lingyun Li; Trisha Fremgen; Erin Murphy; Angela Quinn; Stephen L. Madden; Hans Peter Biemann; Bing Wang; Aharon Cohen; Svetlana Komarnitsky; Kate Jancsics; Brad Hirth; Christopher G.F. Cooper; Edward Lee; Sean Wilson; Roy Krumbholz; Steven Schmid; Yibin Xiang; Michael Booker; James Lillie; Kara Carter

doi:10.1371/journal.pone.0033823

SCD1 inhibition causes cancer cell death by depleting mono-unsaturated fatty acids

Paul Mason
, Beirong Liang
, Lingyun Li
, Trisha Fremgen
, Erin Murphy
, Angela Quinn
, Stephen L. Madden
, Hans Peter Biemann
, Bing Wang
, Aharon Cohen
, Svetlana Komarnitsky
, Kate Jancsics
, Brad Hirth
, Christopher G.F. Cooper
, Edward Lee
, Sean Wilson
, Roy Krumbholz
, Steven Schmid
, Yibin Xiang
, Michael Booker

James Lillie, Kara Carter

Research output: Contribution to journal › Article › peer-review

Original language	English
Article number	e33823
Journal	PLoS ONE
Volume	7
Issue number	3
DOIs	https://doi.org/10.1371/journal.pone.0033823
State	Published - Mar 22 2012
Externally published	Yes

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Mason, P., Liang, B., Li, L., Fremgen, T., Murphy, E., Quinn, A., Madden, S. L., Biemann, H. P., Wang, B., Cohen, A., Komarnitsky, S., Jancsics, K., Hirth, B., Cooper, C. G. F., Lee, E., Wilson, S., Krumbholz, R., Schmid, S., Xiang, Y., ... Carter, K. (2012). SCD1 inhibition causes cancer cell death by depleting mono-unsaturated fatty acids. PLoS ONE, 7(3), Article e33823. https://doi.org/10.1371/journal.pone.0033823

Mason, P, Liang, B, Li, L, Fremgen, T, Murphy, E, Quinn, A, Madden, SL, Biemann, HP, Wang, B, Cohen, A, Komarnitsky, S, Jancsics, K, Hirth, B, Cooper, CGF, Lee, E, Wilson, S, Krumbholz, R, Schmid, S, Xiang, Y, Booker, M, Lillie, J & Carter, K 2012, 'SCD1 inhibition causes cancer cell death by depleting mono-unsaturated fatty acids', PLoS ONE, vol. 7, no. 3, e33823. https://doi.org/10.1371/journal.pone.0033823

@article{12eab4d5584a444593c986949b556037,

title = "SCD1 inhibition causes cancer cell death by depleting mono-unsaturated fatty acids",

author = "Paul Mason and Beirong Liang and Lingyun Li and Trisha Fremgen and Erin Murphy and Angela Quinn and Madden, \{Stephen L.\} and Biemann, \{Hans Peter\} and Bing Wang and Aharon Cohen and Svetlana Komarnitsky and Kate Jancsics and Brad Hirth and Cooper, \{Christopher G.F.\} and Edward Lee and Sean Wilson and Roy Krumbholz and Steven Schmid and Yibin Xiang and Michael Booker and James Lillie and Kara Carter",

note = "Increased metabolism is a requirement for tumor cell proliferation. To understand the dependence of tumor cells on fatty acid metabolism, we evaluated various nodes of the fatty acid synthesis pathway. Using RNAi we have demonstrated that depletion of fatty-acid synthesis pathway enzymes SCD1, FASN, or ACC1 in HCT116 colon cancer cells results in cytotoxicity that is reversible by addition of exogenous fatty acids.",

year = "2012",

month = mar,

day = "22",

doi = "10.1371/journal.pone.0033823",

language = "English",

volume = "7",

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TY - JOUR

T1 - SCD1 inhibition causes cancer cell death by depleting mono-unsaturated fatty acids

AU - Mason, Paul

AU - Liang, Beirong

AU - Li, Lingyun

AU - Fremgen, Trisha

AU - Murphy, Erin

AU - Quinn, Angela

AU - Madden, Stephen L.

AU - Biemann, Hans Peter

AU - Wang, Bing

AU - Cohen, Aharon

AU - Komarnitsky, Svetlana

AU - Jancsics, Kate

AU - Hirth, Brad

AU - Cooper, Christopher G.F.

AU - Lee, Edward

AU - Wilson, Sean

AU - Krumbholz, Roy

AU - Schmid, Steven

AU - Xiang, Yibin

AU - Booker, Michael

AU - Lillie, James

AU - Carter, Kara

N1 - Increased metabolism is a requirement for tumor cell proliferation. To understand the dependence of tumor cells on fatty acid metabolism, we evaluated various nodes of the fatty acid synthesis pathway. Using RNAi we have demonstrated that depletion of fatty-acid synthesis pathway enzymes SCD1, FASN, or ACC1 in HCT116 colon cancer cells results in cytotoxicity that is reversible by addition of exogenous fatty acids.

PY - 2012/3/22

Y1 - 2012/3/22

UR - https://www.scopus.com/pages/publications/84863388391

UR - https://www.scopus.com/pages/publications/84863388391#tab=citedBy

U2 - 10.1371/journal.pone.0033823

DO - 10.1371/journal.pone.0033823

M3 - Article

SN - 1932-6203

VL - 7

JO - PLoS ONE

JF - PLoS ONE

IS - 3

M1 - e33823

ER -

SCD1 inhibition causes cancer cell death by depleting mono-unsaturated fatty acids

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