Safety, tolerability, pharmacokinetics, and antimalarial efficacy of a novel Plasmodium falciparum ATP4 inhibitor SJ733: a first-in-human and induced blood-stage malaria phase 1a/b trial

Aditya H. Gaur; James S. McCarthy; John C. Panetta; Ronald H. Dallas; John Woodford; Li Tang; Amber M. Smith; Tracy B. Stewart; Kristen C. Branum; Burgess B. Freeman; Nehali D. Patel; Elizabeth John; Stephan Chalon; Shelley Ost; Ryan N. Heine; Julie L. Richardson; Robbin Christensen; Patricia M. Flynn; Yvonne Van Gessel; Branko Mitasev; Jörg J. Möhrle; Fabian Gusovsky; Lidiya Bebrevska; R. Kiplin Guy

doi:10.1016/S1473-3099(19)30611-5

Safety, tolerability, pharmacokinetics, and antimalarial efficacy of a novel Plasmodium falciparum ATP4 inhibitor SJ733: a first-in-human and induced blood-stage malaria phase 1a/b trial

Aditya H. Gaur
, James S. McCarthy
, John C. Panetta
, Ronald H. Dallas
, John Woodford
, Li Tang
, Amber M. Smith
, Tracy B. Stewart
, Kristen C. Branum
, Burgess B. Freeman
, Nehali D. Patel
, Elizabeth John
, Stephan Chalon
, Shelley Ost
, Ryan N. Heine
, Julie L. Richardson
, Robbin Christensen
, Patricia M. Flynn
, Yvonne Van Gessel
, Branko Mitasev

Jörg J. Möhrle, Fabian Gusovsky, Lidiya Bebrevska, R. Kiplin Guy

Research output: Contribution to journal › Article › peer-review

Original language	English
Pages (from-to)	964-975
Number of pages	12
Journal	The Lancet Infectious Diseases
Volume	20
Issue number	8
DOIs	https://doi.org/10.1016/S1473-3099(19)30611-5
State	Published - Aug 2020

ASJC Scopus Subject Areas

Infectious Diseases

Access to Document

10.1016/S1473-3099(19)30611-5

OpenUrl availability

Full text

Cite this

Gaur, A. H., McCarthy, J. S., Panetta, J. C., Dallas, R. H., Woodford, J., Tang, L., Smith, A. M., Stewart, T. B., Branum, K. C., Freeman, B. B., Patel, N. D., John, E., Chalon, S., Ost, S., Heine, R. N., Richardson, J. L., Christensen, R., Flynn, P. M., Van Gessel, Y., ... Guy, R. K. (2020). Safety, tolerability, pharmacokinetics, and antimalarial efficacy of a novel Plasmodium falciparum ATP4 inhibitor SJ733: a first-in-human and induced blood-stage malaria phase 1a/b trial. The Lancet Infectious Diseases, 20(8), 964-975. https://doi.org/10.1016/S1473-3099(19)30611-5

Safety, tolerability, pharmacokinetics, and antimalarial efficacy of a novel Plasmodium falciparum ATP4 inhibitor SJ733: a first-in-human and induced blood-stage malaria phase 1a/b trial. / Gaur, Aditya H.; McCarthy, James S.; Panetta, John C. et al.
In: The Lancet Infectious Diseases, Vol. 20, No. 8, 08.2020, p. 964-975.

Research output: Contribution to journal › Article › peer-review

Gaur, AH, McCarthy, JS, Panetta, JC, Dallas, RH, Woodford, J, Tang, L, Smith, AM, Stewart, TB, Branum, KC, Freeman, BB, Patel, ND, John, E, Chalon, S, Ost, S, Heine, RN, Richardson, JL, Christensen, R, Flynn, PM, Van Gessel, Y, Mitasev, B, Möhrle, JJ, Gusovsky, F, Bebrevska, L & Guy, RK 2020, 'Safety, tolerability, pharmacokinetics, and antimalarial efficacy of a novel Plasmodium falciparum ATP4 inhibitor SJ733: a first-in-human and induced blood-stage malaria phase 1a/b trial', The Lancet Infectious Diseases, vol. 20, no. 8, pp. 964-975. https://doi.org/10.1016/S1473-3099(19)30611-5

@article{43f1eb62bfb44a2493c9e94071851bd1,

title = "Safety, tolerability, pharmacokinetics, and antimalarial efficacy of a novel Plasmodium falciparum ATP4 inhibitor SJ733: a first-in-human and induced blood-stage malaria phase 1a/b trial",

author = "Gaur, \{Aditya H.\} and McCarthy, \{James S.\} and Panetta, \{John C.\} and Dallas, \{Ronald H.\} and John Woodford and Li Tang and Smith, \{Amber M.\} and Stewart, \{Tracy B.\} and Branum, \{Kristen C.\} and Freeman, \{Burgess B.\} and Patel, \{Nehali D.\} and Elizabeth John and Stephan Chalon and Shelley Ost and Heine, \{Ryan N.\} and Richardson, \{Julie L.\} and Robbin Christensen and Flynn, \{Patricia M.\} and \{Van Gessel\}, Yvonne and Branko Mitasev and M{\"o}hrle, \{J{\"o}rg J.\} and Fabian Gusovsky and Lidiya Bebrevska and Guy, \{R. Kiplin\}",

note = "Publisher Copyright: {\textcopyright} 2020 Elsevier Ltd",

year = "2020",

month = aug,

doi = "10.1016/S1473-3099(19)30611-5",

language = "English",

volume = "20",

pages = "964--975",

journal = "The Lancet Infectious Diseases",

issn = "1473-3099",

number = "8",

}

TY - JOUR

T1 - Safety, tolerability, pharmacokinetics, and antimalarial efficacy of a novel Plasmodium falciparum ATP4 inhibitor SJ733

T2 - a first-in-human and induced blood-stage malaria phase 1a/b trial

AU - Gaur, Aditya H.

AU - McCarthy, James S.

AU - Panetta, John C.

AU - Dallas, Ronald H.

AU - Woodford, John

AU - Tang, Li

AU - Smith, Amber M.

AU - Stewart, Tracy B.

AU - Branum, Kristen C.

AU - Freeman, Burgess B.

AU - Patel, Nehali D.

AU - John, Elizabeth

AU - Chalon, Stephan

AU - Ost, Shelley

AU - Heine, Ryan N.

AU - Richardson, Julie L.

AU - Christensen, Robbin

AU - Flynn, Patricia M.

AU - Van Gessel, Yvonne

AU - Mitasev, Branko

AU - Möhrle, Jörg J.

AU - Gusovsky, Fabian

AU - Bebrevska, Lidiya

AU - Guy, R. Kiplin

PY - 2020/8

Y1 - 2020/8

UR - https://www.scopus.com/pages/publications/85088841789

UR - https://www.scopus.com/pages/publications/85088841789#tab=citedBy

U2 - 10.1016/S1473-3099(19)30611-5

DO - 10.1016/S1473-3099(19)30611-5

M3 - Article

C2 - 32275867

AN - SCOPUS:85088841789

SN - 1473-3099

VL - 20

SP - 964

EP - 975

JO - The Lancet Infectious Diseases

JF - The Lancet Infectious Diseases

IS - 8

ER -

Safety, tolerability, pharmacokinetics, and antimalarial efficacy of a novel Plasmodium falciparum ATP4 inhibitor SJ733: a first-in-human and induced blood-stage malaria phase 1a/b trial

ASJC Scopus Subject Areas

Access to Document

OpenUrl availability

Other files and links

Cite this