Safety, tolerability, pharmacokinetics, and antimalarial efficacy of a novel Plasmodium falciparum ATP4 inhibitor SJ733: a first-in-human and induced blood-stage malaria phase 1a/b trial

Aditya H. Gaur; James S. McCarthy; John C. Panetta; Ronald H. Dallas; John Woodford; Li Tang; Amber M. Smith; Tracy B. Stewart; Kristen C. Branum; Burgess B. Freeman; Nehali D. Patel; Elizabeth John; Stephan Chalon; Shelley Ost; Ryan N. Heine; Julie L. Richardson; Robbin Christensen; Patricia M. Flynn; Yvonne Van Gessel; Branko Mitasev; Jörg J. Möhrle; Fabian Gusovsky; Lidiya Bebrevska; R. Kiplin Guy

doi:10.1016/S1473-3099(19)30611-5

Safety, tolerability, pharmacokinetics, and antimalarial efficacy of a novel Plasmodium falciparum ATP4 inhibitor SJ733: a first-in-human and induced blood-stage malaria phase 1a/b trial

Aditya H. Gaur, James S. McCarthy, John C. Panetta, Ronald H. Dallas, John Woodford, Li Tang, Amber M. Smith, Tracy B. Stewart, Kristen C. Branum, Burgess B. Freeman, Nehali D. Patel, Elizabeth John, Stephan Chalon, Shelley Ost, Ryan N. Heine, Julie L. Richardson, Robbin Christensen, Patricia M. Flynn, Yvonne Van Gessel, Branko MitasevJörg J. Möhrle, Fabian Gusovsky, Lidiya Bebrevska, R. Kiplin Guy

Research output: Contribution to journal › Article › peer-review

Original language	English
Pages (from-to)	964-975
Number of pages	12
Journal	The Lancet Infectious Diseases
Volume	20
Issue number	8
DOIs	https://doi.org/10.1016/S1473-3099(19)30611-5
State	Published - Aug 2020

ASJC Scopus Subject Areas

Infectious Diseases

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10.1016/S1473-3099(19)30611-5

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Gaur, A. H., McCarthy, J. S., Panetta, J. C., Dallas, R. H., Woodford, J., Tang, L., Smith, A. M., Stewart, T. B., Branum, K. C., Freeman, B. B., Patel, N. D., John, E., Chalon, S., Ost, S., Heine, R. N., Richardson, J. L., Christensen, R., Flynn, P. M., Van Gessel, Y., ... Guy, R. K. (2020). Safety, tolerability, pharmacokinetics, and antimalarial efficacy of a novel Plasmodium falciparum ATP4 inhibitor SJ733: a first-in-human and induced blood-stage malaria phase 1a/b trial. The Lancet Infectious Diseases, 20(8), 964-975. https://doi.org/10.1016/S1473-3099(19)30611-5

Safety, tolerability, pharmacokinetics, and antimalarial efficacy of a novel Plasmodium falciparum ATP4 inhibitor SJ733: a first-in-human and induced blood-stage malaria phase 1a/b trial. / Gaur, Aditya H.; McCarthy, James S.; Panetta, John C. et al.
In: The Lancet Infectious Diseases, Vol. 20, No. 8, 08.2020, p. 964-975.

Research output: Contribution to journal › Article › peer-review

Gaur, AH, McCarthy, JS, Panetta, JC, Dallas, RH, Woodford, J, Tang, L, Smith, AM, Stewart, TB, Branum, KC, Freeman, BB, Patel, ND, John, E, Chalon, S, Ost, S, Heine, RN, Richardson, JL, Christensen, R, Flynn, PM, Van Gessel, Y, Mitasev, B, Möhrle, JJ, Gusovsky, F, Bebrevska, L & Guy, RK 2020, 'Safety, tolerability, pharmacokinetics, and antimalarial efficacy of a novel Plasmodium falciparum ATP4 inhibitor SJ733: a first-in-human and induced blood-stage malaria phase 1a/b trial', The Lancet Infectious Diseases, vol. 20, no. 8, pp. 964-975. https://doi.org/10.1016/S1473-3099(19)30611-5

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Safety, tolerability, pharmacokinetics, and antimalarial efficacy of a novel Plasmodium falciparum ATP4 inhibitor SJ733: a first-in-human and induced blood-stage malaria phase 1a/b trial

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