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Safety, Tolerability, and Pharmacokinetics of ARC-520 Injection, an RNA Interference-Based Therapeutic for the Treatment of Chronic Hepatitis B Virus Infection, in Healthy Volunteers

  • Thomas Schluep
  • , Jason Lickliter
  • , James Hamilton
  • , David L. Lewis
  • , Ching Lung Lai
  • , Johnson Y.N. Lau
  • , Stephen A. Locarnini
  • , Robert G. Gish
  • , Bruce D. Given

Research output: Contribution to journalArticlepeer-review

Original languageEnglish
Pages (from-to)350-362
Number of pages13
JournalClinical Pharmacology in Drug Development
Volume6
Issue number4
DOIs
StatePublished - Jul 1 2017
Externally publishedYes

ASJC Scopus Subject Areas

  • Pharmaceutical Science
  • Pharmacology (medical)

Keywords

  • RNA interference
  • RNAi
  • hepatitis B
  • pharmacokinetics
  • pharmacology
  • phase 1
  • safety
  • tolerability
  • treatment
  • viral hepatitis
  • volunteers
  • Humans
  • Middle Aged
  • Half-Life
  • Male
  • Healthy Volunteers
  • Young Adult
  • RNA Interference
  • Adult
  • Female
  • Histamine Antagonists/administration & dosage
  • Double-Blind Method
  • Hepatitis B, Chronic/drug therapy
  • Pre-Exposure Prophylaxis/methods
  • Antiviral Agents/administration & dosage
  • Infusions, Intravenous

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