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Role of statins in cerebral vasospasm

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

3-Hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase inhibitors, commonly known as statins, are widely used clinically for their lipid lowering properties. Recent evidence shows that statins are also effective in ameliorating cerebral vasospasm, which occurs as sequelae of subarachnoid haemorrhage. This review focuses on the pleiotropic effects of statins, and the putative mechanisms involved in statin mediated attenuation of cerebral vasospasm. © 2008 Springer-Verlag.
Original languageEnglish
Title of host publicationCerebral Vasospasm
Subtitle of host publicationNew Strategies in Research and Treatment
PublisherSpringer Vienna
Pages287-290
Number of pages4
Edition104
ISBN (Electronic)978-3-211-75718-5
ISBN (Print)9783211757178, 978-3-211-99916-5
DOIs
StatePublished - Mar 25 2008

Publication series

NameActa Neurochirurgica, Supplementum
Number104
ISSN (Print)0065-1419
ISSN (Electronic)2197-8395

ASJC Scopus Subject Areas

  • Surgery
  • Clinical Neurology

Keywords

  • Akt
  • Cerebral vasospasm
  • Rho
  • eNOS
  • pleiotropic effects
  • statin
  • subarachnoid haemorrhage
  • Nitric Oxide Synthase Type III/genetics
  • Vasospasm, Intracranial/drug therapy
  • Animals
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use
  • Muscle, Smooth, Vascular/enzymology
  • Disease Models, Animal
  • Subarachnoid Hemorrhage/drug therapy

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