RIGOR Guidelines: Escalating STAIR and STEPS for Effective Translational Research

Paul A. Lapchak, John H. Zhang, Linda J. Noble-Haeusslein

Research output: Contribution to journalArticlepeer-review

Abstract

Stroke continues to be a serious and significant health problem in the USA and worldwide. This article will emphasize the need for good laboratory practices, transparent scientific reporting, and the use of translational research models representative of the disease state to develop effective treatments. This will allow for the testing and development of new innovative strategies so that efficacious therapies can be developed to treat ischemic and hemorrhagic stroke. This article recommends guidelines for effective translational research, most importantly, the need for study blinding, study group randomization, power analysis, accurate statistical analysis, and a conflict of interest statement. Additional guidelines to ensure reproducibility of results and confirmation of efficacy in multiple species are discussed.

Original languageEnglish
Pages (from-to)279-285
Number of pages7
JournalTranslational Stroke Research
Volume4
Issue number3
DOIs
StatePublished - Jun 2013

ASJC Scopus Subject Areas

  • General Neuroscience
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine

Keywords

  • Brain
  • Clinical Trial
  • Hemorrhage
  • ICH
  • NIHSS
  • RIGOR
  • SAH
  • STAIR
  • STEPS
  • Stroke
  • Translational
  • History, 17th Century
  • Humans
  • Stroke/history
  • Male
  • Female
  • History, Ancient
  • History, 20th Century
  • History, 16th Century
  • History, 18th Century
  • Clinical Laboratory Techniques/standards
  • Disclosure
  • Randomized Controlled Trials as Topic
  • Stem Cell Transplantation/methods
  • History, 19th Century
  • Aged
  • Translational Research, Biomedical
  • Research Design
  • Practice Guidelines as Topic

Cite this