TY - JOUR
T1 - Response to Letter Regarding Article, "norrin Protected Blood-Brain Barrier via Frizzled-4/β-Catenin Pathway after Subarachnoid Hemorrhage in Rats"
AU - Chen, Yujie
AU - Feng, Hua
AU - Zhang, John H.
N1 - We appreciate Zuo and Xu1 for their interest in our study and their concerns about the frizzled-4 small interfering RNA (siRNA) efficacy in our experiments. We concur that the magnitude of suppression of siRNA in vivo was less than that achieved in vitro, therefore we used a pool of 3 different frizzled-4 siRNA duplexes to improve the knockdown efficiency.
PY - 2015/4/20
Y1 - 2015/4/20
KW - Eye Proteins/biosynthesis
KW - Frizzled Receptors/biosynthesis
KW - Animals
KW - Blood-Brain Barrier/metabolism
KW - Male
KW - Nerve Tissue Proteins/biosynthesis
KW - Subarachnoid Hemorrhage/metabolism
KW - beta Catenin/biosynthesis
UR - http://www.scopus.com/inward/record.url?scp=84937559506&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84937559506&partnerID=8YFLogxK
UR - https://www.mendeley.com/catalogue/5c96eb00-cf30-3737-8069-701633bb39bd/
U2 - 10.1161/STROKEAHA.115.008779
DO - 10.1161/STROKEAHA.115.008779
M3 - Letter
C2 - 25721016
SN - 0039-2499
VL - 46
SP - e91
JO - Stroke
JF - Stroke
IS - 4
ER -