Reprogramming of miR-181a/DNA methylation patterns contribute to the maternal nicotine exposure-induced fetal programming of cardiac ischemia-sensitive phenotype in postnatal life

Jie Jian, Peng Zhang, Yong Li, Bailin Liu, Yanyan Zhang, Lubo Zhang, Xuesi M. Shao, Jian Zhuang, Daliao Xiao

Research output: Contribution to journalArticlepeer-review

Original languageEnglish
Pages (from-to)11820-11836
Number of pages17
JournalTheranostics
Volume10
Issue number25
DOIs
StatePublished - 2020

ASJC Scopus Subject Areas

  • Medicine (miscellaneous)
  • Pharmacology, Toxicology and Pharmaceutics (miscellaneous)

Keywords

  • Cardiac ischemia/reperfusion injury
  • DNA methylation
  • MiR-181a
  • Perinatal nicotine
  • Fetal Development/drug effects
  • Transforming Growth Factor beta/metabolism
  • Embryo, Mammalian
  • CpG Islands/genetics
  • Male
  • Prenatal Exposure Delayed Effects/genetics
  • Promoter Regions, Genetic/genetics
  • Smad Proteins/metabolism
  • Smoking/adverse effects
  • DNA Methylation
  • Autophagy/genetics
  • Female
  • Heart/embryology
  • Maternal Exposure/adverse effects
  • Disease Models, Animal
  • Ataxia Telangiectasia Mutated Proteins/genetics
  • Signal Transduction/genetics
  • Nicotine/administration & dosage
  • Rats
  • RNA, Long Noncoding/metabolism
  • Gene Expression Regulation, Developmental/drug effects
  • Pregnancy
  • Myocardial Ischemia/genetics
  • Animals
  • Myocardium/metabolism
  • MicroRNAs/antagonists & inhibitors

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