TY - JOUR
T1 - Recent Thymic Emigrants and Tregs Expressing CD31 and CD45RA Are Decreased at Day 100 and Prognostic for Chronic GvHD in Children: Results From the Applied Biomarkers of Late Effects (ABLE)/Pediatric Blood and Marrow Transplant Consortium 1202 Study
AU - Cuvelier, Geoff D.E.
AU - Nemecek, Eneida R.
AU - Wahlstrom, Justin T.
AU - Harris, Andrew C.
AU - Pulsipher, Michael A.
AU - Lewis, Victor
AU - Bittencourt, Henrique
AU - Choi, Sung Won
AU - Kitko, Carrie L.
AU - Caywood, Emi
AU - Bhatia, Monica
AU - Kasow, Kmberly
AU - Jacobsohn, David A.
AU - Oshrine, Benjamin R.
AU - Kheradpour, Albert
AU - Chaudhury, Sonali
AU - Chewning, Joseph H.
AU - Schechter, Tal
AU - Flower, Allyson
AU - Coulter, Don W.
AU - Joyce, Michael
AU - Savasan, Sureyya
AU - Pawlowska, Anna
AU - Megason, Gail
AU - Mitchell, David
AU - Cheerva, Alexandra
AU - Kariminia, Amina
AU - Halevy, Anat
AU - Schultz, Kirk R.
N1 - Background: Our group and others (Greinix BBMT 2015) have shown that higher proportions of recent thymic emigrants (RTEs: CD4+CD45RA+CD31+) at d100 are a prognostic biomarker for chronic GvHD in adults. We sought to understand whether RTEs, as well as regulatory T cells (CD4+CD25+CD127Lo) that co-express naïve and recently emigrated markers (CD45RA+CD31+; Treg RTEs) were prognostic at d100 for pediatric cGvHD.
PY - 2018/3/1
Y1 - 2018/3/1
N2 - Background: Our group and others (Greinix BBMT 2015) have shown that higher proportions of recent thymic emigrants (RTEs: CD4+CD45RA+CD31+) at d100 are a prognostic biomarker for chronic GvHD in adults. We sought to understand whether RTEs, as well as regulatory T cells (CD4+CD25+CD127Lo) that co-express naive and recently emigrated markers (CD45RA+CD31+; Treg RTEs) were prognostic at d100 for pediatric cGvHD. Methods: Allo-HCT patients (1.5x or
AB - Background: Our group and others (Greinix BBMT 2015) have shown that higher proportions of recent thymic emigrants (RTEs: CD4+CD45RA+CD31+) at d100 are a prognostic biomarker for chronic GvHD in adults. We sought to understand whether RTEs, as well as regulatory T cells (CD4+CD25+CD127Lo) that co-express naive and recently emigrated markers (CD45RA+CD31+; Treg RTEs) were prognostic at d100 for pediatric cGvHD. Methods: Allo-HCT patients (1.5x or
UR - https://www.bbmt.org/article/S1083-8791(17)30919-9/fulltext
UR - https://www.mendeley.com/catalogue/5ba0df2f-a7cd-34c5-80d7-12152488918d/
U2 - 10.1016/J.BBMT.2017.12.030
DO - 10.1016/J.BBMT.2017.12.030
M3 - Meeting abstract
VL - 24
SP - S114-S115
JO - Biology of Blood and Marrow Transplantation
JF - Biology of Blood and Marrow Transplantation
IS - 3
ER -